Results 1 to 10 of about 5,346 (203)
Sodium iodide symporter-targeted gene therapy in glioblastoma [PDF]
Molecular Therapy: Oncolytics, 2023 Fil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba.
Juan Pablo Nicola +1 more
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Tumor microenvironment affects exogenous sodium/iodide symporter expression [PDF]
Translational Oncology, 2021 For decades, sodium/iodide symporter NIS-mediated iodide uptake has played a crucial role in the radioactive ablation of thyroid cancer cells. NIS-based gene therapy has also become a promising tool for the treatment of tumors of extrathyroidal origin ...
Fabio Castillo-Rivera +9 more
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Structural insights into the mechanism of the sodium/iodide symporter. [PDF]
Nature, 2022 The sodium/iodide symporter (NIS) is the essential plasma membrane protein that mediates active iodide (I-) transport into the thyroid gland, the first step in the biosynthesis of the thyroid hormones-the master regulators of intermediary metabolism. NIS couples the inward translocation of I- against its electrochemical gradient to the inward transport
Ravera S +7 more
europepmc +3 more sources
Sodium Iodide Symporter (NIS) and Thyroid [PDF]
HORMONES, 2002 idase (TPO) and incorporation into tyrosyl residues along the thyroglobulin (Tg) backbone. The thyroid hormones T3 and T4 are synthesized by coupling of two iodotyrosine residues and stored in the colloid. All of these steps are stimulated by pituitary-derived thyroid stimulating hormone (TSH), which interacts with the TSH receptor at the basolateral ...
Christine Spitzweg, John C. Morris
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High molar activity [18F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET [PDF]
EJNMMI Radiopharmacy and Chemistry, 2022 Background Sodium iodide symporter (NIS) imaging by positron emission tomography (PET) is gaining traction in nuclear medicine, with an increasing number of human studies being published using fluorine-18 radiolabelled tetrafluoroborate ([18F]TFB ...
Dmitry Soloviev +5 more
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Regulation of the sodium iodide symporter by iodide in FRTL-5 cells [PDF]
European Journal of Endocrinology, 2001 OBJECTIVE: The acute decrease in iodide organification in the thyroid in response to excess iodide is termed the acute Wolff-Chaikoff effect and normal organification resumes in spite of continued high plasma iodide concentrations (escape from the acute Wolff-Chaikoff effect).
PH Eng +4 more
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Exogenous Melatonin Protects against Oxidative Damage to Membrane Lipids Caused by Some Sodium/Iodide Symporter Inhibitors in the Thyroid [PDF]
Antioxidants, 2023 The thyroid gland is the primary site of sodium/iodide symporter (NIS), an intrinsic plasma membrane protein responsible for the active uptake of iodine, which is indispensable for thyroid hormone synthesis.
Aleksandra K. Gładysz +2 more
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The sodium iodide symporter (NIS) as theranostic gene: its emerging role in new imaging modalities and non-viral gene therapy [PDF]
EJNMMI Research, 2022 Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies rely on image-guided selective NIS gene transfer in non-thyroidal tumors followed by ...
Carolin Kitzberger +15 more
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Dimerization of the Sodium/Iodide Symporter. [PDF]
Thyroid, 2019 Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become unresponsive to radioiodide therapy, with poor clinical outcome.
Thompson RJ +11 more
europepmc +4 more sources
Post-transcriptional Regulation of the Sodium/Iodide Symporter by Thyrotropin [PDF]
Journal of Biological Chemistry, 2001 The Na(+)/I(-) symporter (NIS) is a key plasma membrane glycoprotein that mediates active I(-) transport in the thyroid gland (Dai, G., Levy, O., and Carrasco, N. (1996) Nature 379, 458-460), the first step in thyroid hormone biogenesis. Whereas relatively little is known about the mechanisms by which thyrotropin (TSH), the main hormonal regulator of ...
Claudia A. Riedel +2 more
openalex +5 more sources