Tumor microenvironment affects exogenous sodium/iodide symporter expression [PDF]
Translational Oncology, 2021 For decades, sodium/iodide symporter NIS-mediated iodide uptake has played a crucial role in the radioactive ablation of thyroid cancer cells. NIS-based gene therapy has also become a promising tool for the treatment of tumors of extrathyroidal origin ...
Fabio Castillo-Rivera +9 more
doaj +5 more sources
The sodium/iodide symporter is a nitrate transporter in the human salivary gland [PDF]
Redox BiologyRationale: The entero-salivary circulation of inorganic nitrate (NO3−) involves the absorption of dietary nitrate in the gut and active uptake from blood by the salivary glands, leading to a 20-25-fold concentration in saliva.
Gaia Picozzi +9 more
doaj +3 more sources
The extra-thyroidal distribution of sodium iodide symporter [PDF]
Frontiers in EndocrinologyThe intrinsic transmembrane protein known as sodium iodide symporter (NIS) facilitates the active transport of iodide across the basolateral membrane of thyroid follicular cells.
Rinae Prisca Gadisi +2 more
doaj +2 more sources
Exogenous Melatonin Protects against Oxidative Damage to Membrane Lipids Caused by Some Sodium/Iodide Symporter Inhibitors in the Thyroid [PDF]
Antioxidants, 2023 The thyroid gland is the primary site of sodium/iodide symporter (NIS), an intrinsic plasma membrane protein responsible for the active uptake of iodine, which is indispensable for thyroid hormone synthesis.
Aleksandra K. Gładysz +2 more
doaj +2 more sources
High molar activity [18F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET [PDF]
EJNMMI Radiopharmacy and Chemistry, 2022 Background Sodium iodide symporter (NIS) imaging by positron emission tomography (PET) is gaining traction in nuclear medicine, with an increasing number of human studies being published using fluorine-18 radiolabelled tetrafluoroborate ([18F]TFB ...
Dmitry Soloviev +5 more
doaj +3 more sources
The sodium iodide symporter (NIS) as theranostic gene: its emerging role in new imaging modalities and non-viral gene therapy [PDF]
EJNMMI Research, 2022 Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies rely on image-guided selective NIS gene transfer in non-thyroidal tumors followed by ...
Carolin Kitzberger +15 more
doaj +2 more sources
Dimerization of the Sodium/Iodide Symporter. [PDF]
Thyroid, 2019 Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become unresponsive to radioiodide therapy, with poor clinical outcome.
Thompson RJ +11 more
europepmc +3 more sources
Translational Research Using Sodium/Iodide Symporter [PDF]
Journal of Korean Endocrine Society, 2006 184 1915년에 갑상선 조직에 요오드가 선택적으로 축적된다 는 사실이 밝혀졌고, 그 이후 갑상선 질환의 진단과 치료에 방사성요오드가 널리 이용되게 되었다. 갑상선 조직은 요오 드를 혈액에서부터 20~40배 정도 높은 농도로 축적한다. 약 60년 전부터 방사성요오드를 갑상선 기능을 측정하는 추적 자로 사용하였고, 곧이어 갑상선기능항진증과 갑상선암에서 I-131를 치료제로 사용하게 되었다. 그러나 갑상선 세포에 요오드가 선택적으로 섭취되는 기 전은 최근에야 밝혀졌다.
June-Key Chung, Joo Hyun Kang
openalex +2 more sources
Sodium iodide symporter-targeted gene therapy in glioblastoma [PDF]
Molecular Therapy: Oncolytics, 2023 Juan Pablo Nicola +1 more
doaj +2 more sources
Selective sodium iodide symporter (NIS) gene therapy of glioblastoma mediated by EGFR-targeted lipopolyplexes [PDF]
Molecular Therapy: Oncolytics, 2021 Lipo-oligomers, post-functionalized with ligands to enhance targeting, represent promising new vehicles for the tumor-specific delivery of therapeutic genes such as the sodium iodide symporter (NIS). Due to its iodide trapping activity, NIS is a powerful
Rebekka Spellerberg +14 more
doaj +2 more sources