Results 91 to 100 of about 22,958 (276)

Combining Transfer of TTF-1 and Pax-8 Gene: a Potential Strategy to Promote Radioiodine Therapy of Thyroid Carcinoma [PDF]

, 2011
Cotransfer of TTF-1 and Pax-8 gene to tumor cells, resulting in the reexpression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to ...
Anren Kuang, Da Mu, Rui Huang, Suping Li, Xiaojuan Ma   +4 more
core   +1 more source

NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]

, 2018
Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena, Bongiovanni, Massimo, Carrasco, Nancy, Chartoumpekis, Dionysios V, Habeos, Ioannis, Juvenal, Guillermo Juan, Kensler, Thomas W., Liao, Xiao-Hui, Ntalampyra, Eleni, Refetoff, Samuel, Renaud, Cédric O., Ris Stalpers, Carrie, Rossich, Luciano Esteban, Santisteban, Pilar, Somm, Emmanuel, Sykiotis, Gerasimos P., Thomasz, Lisa, Trougakos, Ioannis P, Yamamoto, Masayuki, Ziros, Panos G   +19 more
core   +1 more source

Differentiated thyroid cancer: Growth factors, oncogenes and environmental influences [PDF]

Archive of Oncology, 2003
The present data of growth factors, oncogenes, tumor-suppressor-genes and environmental factors can be summarized in thus: thyrotropin, growth factors and other hormones do increase thyrocyte growth and specific mutations of growth factor receptors ...
Paunović Ivan R.
doaj   +1 more source

Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer Risk

Cancer Medicine, Volume 14, Issue 13, July 2025.
ABSTRACT Aim To investigate the mechanistic aspects of inflammation and oxidative stress and their association with thyroid cancer risk. Methods We have systematically searched the PubMed and Web of Science databases to perform a comprehensive analysis of the pathogenic mechanisms that link obesity, inflammation, and oxidative stress to thyroid cancer.
Bo‐Tao Zhang, Mao Guo, Liu‐Rui Yang, Yang Zeng, Jun Jiang   +4 more
wiley   +1 more source

Perchlorate, nitrate, and thiocyanate: Environmental relevant NIS-inhibitors pollutants and their impact on thyroid function and human health

Frontiers in Endocrinology, 2022
Thyroid disruptors are found in food, atmosphere, soil, and water. These contaminants interfere with the thyroid function through the impairment of thyroid hormone synthesis, plasma transport, peripheral metabolism, transport into the target cells, and ...
Caroline Serrano-Nascimento, Caroline Serrano-Nascimento, Maria Tereza Nunes   +2 more
doaj   +1 more source

PTTG and PBF repress the human sodium iodide symporter [PDF]

Oncogene, 2007
The ability of the thyroid to accumulate iodide provides the basis for radioiodine ablation of differentiated thyroid cancers and their metastases. Most thyroid tumours exhibit reduced iodide uptake, although the mechanisms accounting for this remain poorly understood.
Kristien Boelaert, Margaret C. Eggo, T Kogai, Vicki Smith, Jayne A. Franklyn, John Watkinson, L Tannahill, AL Stratford, Christopher McCabe   +8 more
openaire   +3 more sources

Measles to the Rescue: A Review of Oncolytic Measles Virus [PDF]

, 2016
Oncolytic virotherapeutic agents are likely to become serious contenders in cancer treatment. The vaccine strain of measles virus is an agent with an impressive range of oncolytic activity in pre-clinical trials with increasing evidence of safety and ...
Aref, S, Bailey, K, Fielding, A
core   +2 more sources

Treatment of medulloblastoma using an oncolytic measles virus encoding the thyroidal sodium iodide symporter shows enhanced efficacy with radioiodine

BMC Cancer, 2012
Background Medulloblastoma is the most common malignant brain tumor of childhood. Although the clinical outcome for medulloblastoma patients has improved significantly, children afflicted with the disease frequently suffer from debilitating side effects ...
Hutzen Brian, Pierson Christopher R, Russell Stephen J, Galanis Evanthia, Raffel Corey, Studebaker Adam W   +5 more
doaj   +1 more source

Glycosylation of Sodium/Iodide Symporter (NIS) Regulates Its Membrane Translocation and Radioiodine Uptake. [PDF]

PLoS ONE, 2015
Human sodium/iodide symporter (hNIS) protein is a membrane glycoprotein that transports iodide ions into thyroid cells. The function of this membrane protein is closely regulated by post-translational glycosylation.
Taemoon Chung, Hyewon Youn, Chan Joo Yeom, Keon Wook Kang, June-Key Chung   +4 more
doaj   +1 more source

Recent Advances in Cancer Cell Membrane‐Based Nanoparticles and Cancer Cell‐Derived Small Extracellular Vesicles as Drug Delivery Platforms

Advanced NanoBiomed Research, Volume 5, Issue 6, June 2025.
Cancer cell membrane‐based nanoparticles (CCM‐NPs) and cancer cell‐derived small extracellular vesicles (CsEVs) are emerging as promising drug delivery systems for targeted cancer treatment. Advances in nanotechnology have paved the way for innovative drug delivery systems that enhance the effectiveness of cancer treatment.
Wei Zhang, Jingjing Wang, Long Ngo, Li Li, Yuling Wang   +4 more
wiley   +1 more source