Results 131 to 140 of about 22,958 (276)

In vitro effects of natural phytoestrogens on sodium/iodide symporter mediated thyroid iodide uptake by using a differentiated TSH-dependent cell line

Journal of Functional Foods, 2018
Soy food health effects are due to isoflavone (ISF) components functioning as phytoestrogens similar to natural estrogen. Epidemiological data suggest a role of estrogens in pathogenesis of thyroid diseases explaining their prevalence in women.Aim of ...
Patrizia Agretti, Giuseppina De Marco, Antonio Dimida, Eleonora Ferrarini, Massimo Tonacchera   +4 more
doaj  

The Allele Distribution for the rs7250346 SNP in SLC5A5 among Saudis

International Journal of Medical Students, 2015
Background: The sodium/iodide cotransporter solute carrier family 5 member 5 (SLC5A5) is found in the basolateral cell membrane of thyroid follicular epithelial cells as a sodium iodide symporter.
Abdullah T. Eissa
doaj   +1 more source

Effect of iodine on early stage thyroid autonomy [PDF]

, 2011
Thyroid autonomy is a frequent cause of thyrotoxicosis in regions with iodine deficiency. Epidemiological data suggest that iodide may influence the course of pre-existing thyroid autonomy.Making use of FRTL-5 cells stably expressing a constitutively ...
Eszlinger, Markus, Führer, Dagmar, Krohn, Knut, Ludgate, Marian, Müller, Kathrin   +4 more
core   +1 more source

Fluoride Exposure Induces Inhibition of Sodium/Iodide Symporter (NIS) Contributing to Impaired Iodine Absorption and Iodine Deficiency: Molecular Mechanisms of Inhibition and Implications for Public Health

International Journal of Environmental Research and Public Health, 2019
The sodium iodide symporter (NIS) is the plasma membrane glycoprotein that mediates active iodide transport in the thyroid and other tissues, such as the salivary, gastric mucosa, rectal mucosa, bronchial mucosa, placenta and mammary glands.
Declan T Waugh
semanticscholar   +1 more source

MAPK Inhibitors Enhance HDAC Inhibitor-Induced Redifferentiation in Papillary Thyroid Cancer Cells Harboring BRAFV600E: An In Vitro Study

Molecular Therapy: Oncolytics, 2019
Clinical efficacy of redifferentiation therapy with histone deacetylase inhibitor (HDACi) for lethal radioiodine-refractory papillary thyroid cancer (RR-PTC) is urgently needed to be improved.
Hao Fu, Lingxiao Cheng, Yuchen Jin, Lin Cheng, Min Liu, Libo Chen   +5 more
doaj  

Stem Cell Imaging: Tools to Improve Cell Delivery and Viability. [PDF]

, 2016
Stem cell therapy (SCT) has shown very promising preclinical results in a variety of regenerative medicine applications. Nevertheless, the complete utility of this technology remains unrealized. Imaging is a potent tool used in multiple stages of SCT and
Jokerst, Jesse V, Wang, Junxin
core   +3 more sources

Enhancement of 211At Uptake via the Sodium Iodide Symporter by the Addition of Ascorbic Acid in Targeted α-Therapy of Thyroid Cancer

Journal of Nuclear Medicine, 2019
211At is an α-emitter that has similar chemical properties to iodine and is used in targeted α-therapy. In the present study, we added ascorbic acid (AA) to 211At solution to increase the radiochemical purity of astatide and evaluated its efficacy ...
T. Watabe, K. Kaneda-Nakashima, Yuwei Liu, Y. Shirakami, K. Ooe, A. Toyoshima, E. Shimosegawa, M. Fukuda, A. Shinohara, J. Hatazawa   +9 more
semanticscholar   +1 more source

The Sodium/Iodide Symporter (NIS): Molecular Physiology and Preclinical and Clinical Applications.

Annual Review of Physiology, 2017
Active iodide (I-) transport in both the thyroid and some extrathyroidal tissues is mediated by the Na+/I- symporter (NIS). In the thyroid, NIS-mediated I- uptake plays a pivotal role in thyroid hormone (TH) biosynthesis. THs are key during embryonic and
S. Ravera, A. Reyna-Neyra, G. Ferrandino, L. Amzel, N. Carrasco   +4 more
semanticscholar   +1 more source

Effect of progestin on thyroid function in female Wistar rats

Frontiers in Endocrinology
IntroductionTo characterize the influence of female-specific hormones on women’s thyroid function, the study investigated the influence of extra progestin from oral contraceptives on inducing thyroid dysfunction.MethodsSixty female Wistar rats were ...
Honglei Xie, Tingting Qian, Tingting Qian, Lanchun Liu, Rong Sun, Wenjing Che, Meng Zhao, Xin Hou, Haowen Pan, Yue Su, Jia Li, Xiaoqiu Dong, Xiaoqiu Dong, Peng Liu, Peng Liu   +14 more
doaj   +1 more source

The uptake of soluble and nanoparticulate imaging isotope in model liver tumours after intra-venous and intra-arterial administration

, 2015
Delivery of chemotherapeutic drugs to tumours by reformulation as nanoparticles has often been proposed as a means of facilitating increased selective uptake, exploiting the increased permeability of the tumour vasculature.
Bell, Jessica L, Bickley, Stephanie A, Debono, Kelly M, Jones, Stephen K, King, David W, Knox, Karen J, Pang, Jian H, Parish, Christopher, Philip, Lee A, Senden, Tim J, Stephens, Ross W, Tanudji, Marcel R, Tapner, Michael J., Winter, Jillean G   +13 more
core   +1 more source