Results 151 to 160 of about 22,958 (276)

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition

Environment International, 2019
In support of the Endocrine Disruptor Screening Program (EDSP), the U.S.EPA's Office of Research and Development (ORD) is developing high-throughput screening (HTS) approaches to identify chemicals that alter target sites in the thyroid hormone (TH ...
Jun Wang, Daniel R. Hallinger, Ashley S. Murr, Angela R. Buckalew, Ryan R. Lougee, Ann M. Richard, Susan C. Laws, Tammy E. Stoker   +7 more
doaj  

Advances in molecular mechanisms of iodine-131 therapy resistance in thyroid carcinoma

Shanghai Jiaotong Daxue xuebao. Yixue ban
Thyroid cancer is the most common malignant tumor of the endocrine system, with differentiated thyroid carcinoma (DTC) accounting for over 90%. Most DTC patients have a good prognosis after systematic treatment, but a few develop dedifferentiation of ...
LIU Shiqi, WANG Hui, FENG Fang
doaj   +1 more source

Selective sodium iodide symporter (NIS) gene therapy of glioblastoma mediated by EGFR-targeted lipopolyplexes

Molecular Therapy: Oncolytics, 2021
Lipo-oligomers, post-functionalized with ligands to enhance targeting, represent promising new vehicles for the tumor-specific delivery of therapeutic genes such as the sodium iodide symporter (NIS). Due to its iodide trapping activity, NIS is a powerful
Rebekka Spellerberg, Teoman Benli-Hoppe, Carolin Kitzberger, Simone Berger, Kathrin A. Schmohl, Nathalie Schwenk, Hsi-Yu Yen, Christian Zach, Franz Schilling, Wolfgang A. Weber, Roland E. Kälin, Rainer Glass, Peter J. Nelson, Ernst Wagner, Christine Spitzweg   +14 more
doaj  

Survivin-Sodium Iodide Symporter Reporter as a Non-Invasive Diagnostic Marker to Differentiate Uterine Leiomyosarcoma from Leiomyoma. [PDF]

Cells, 2023
Garcia N, Ulin M, Yang Q, Ali M, Bosland MC, Zeng W, Chen L, Al-Hendy A.   +7 more
europepmc   +1 more source

Cloning of a functional promoter of the human sodium/iodide-symporter gene [PDF]

, 1998
Michaël Behr, Thomas Schmitt, Celia R. Espinoza, U. Loos   +3 more
openalex   +1 more source

Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell–Mediated Sodium Iodide Symporter (NIS) Gene 131I Therapy

Clinical Cancer Research, 2019
Purpose: The innate tumor homing potential of mesenchymal stem cells (MSCs) has been used for a targeted delivery of the theranostic sodium iodide symporter (NIS) transgene into solid tumors. We have previously shown that external beam radiotherapy (EBRT)
C. Schug, Carolin Kitzberger, W. Sievert, Rebekka Spellerberg, Mariella Tutter, Kathrin A Schmohl, B. Eberlein, T. Biedermann, K. Steiger, C. Zach, M. Schwaiger, G. Multhoff, E. Wagner, P. Nelson, C. Spitzweg   +14 more
semanticscholar   +1 more source

Induction of follicle formation in long-term cultured normal human thyroid cells treated with thyrotropin stimulates iodide uptake but not sodium/iodide symporter messenger RNA and protein expression [PDF]

, 2000
Takahiko Kogai, Francesco Curcio, Shigeyo Hyman, Cornford Em, GA Brent, JM Hershman   +5 more
openalex   +1 more source

The sodium/iodide symporter: State of the art of its molecular characterization

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014
The sodium/iodide symporter (NIS or SLC5A5) is an intrinsic membrane protein implicated in iodide uptake into thyroid follicular cells. It plays a crucial role in iodine metabolism and thyroid regulation and its function is widely exploited in the diagnosis and treatment of benign and malignant thyroid diseases.
Darrouzet, Elisabeth, Lindenthal, Sabine, Marcellin, Didier, Pellequer, Jean-Luc, Pourcher, Thierry   +4 more
openaire   +5 more sources

Прогностическое значение экспрессии натрий-йодного симпортера для высокодифференцированного рака щитовидной железы

Клиническая и экспериментальная тиреоидология, 2015
The clue function of thyroid follicular cells is iodide (I) uptake and thyroid hormones production. NIS mediates the active transport of I into the thyroid follicular cells.
Dmitriy Yur'evich Semenov, Marina Evgen'evna Boriskova, Ul'yana Valentinovna Farafonova, Roman Viktorovich Grozov, Polina Aleksandrovna Pankova, Ekaterina Nikolaevna Smolina   +5 more
doaj   +1 more source

Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo. [PDF]

Cancer Metab, 2023
Dzien P, Mackintosh A, Malviya G, Johnson E, Soloviev D, Brown G, Uribe AH, Nixon C, Lyons SK, Maddocks O, Blyth K, Lewis DY.   +11 more
europepmc   +1 more source