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Interplay between Rac1b and Sodium Iodide symporter expression in thyroid and breast cancers
Liliana Capinha
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Current Drug Targets - Immune, Endocrine & Metabolic Disorders, 2004
The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant.
C H, Baker, J C, Morris
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The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant.
C H, Baker, J C, Morris
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Sodium/iodide symporter in thyroid cancer
Experimental and Clinical Endocrinology & Diabetes, 2001[No abstract available]
C. Mian +5 more
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Sodium Iodide Symporter in Health and Disease
Thyroid, 2001Radioiodine-concentrating activity in thyroid tissues has allowed the use of radioiodine as a diagnostic and therapeutic agent for patients with thyroid disorders such as well-differentiated thyroid cancer. However, some extrathyroidal tissues also take up radioiodine, contributing to unwanted side effects of radioiodine therapy.
D H, Shen +3 more
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Cloning of the Mouse Sodium Iodide Symporter
Thyroid, 2001The iodide-concentrating ability of the thyroid gland is essential to the production of thyroid hormone. We report the nucleotide and amino acid sequence of the mouse sodium iodide symporter (mNIS), which mediates this activity within the thyroid gland.
L A, Pinke +5 more
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A nonradioactive iodide uptake assay for sodium iodide symporter function
Analytical Biochemistry, 2010The standard assay for sodium iodide symporter (NIS) function is based on the measurement of radioiodide uptake ((125)I) in NIS-expressing cells. However, cost and safety issues have limited the method from being used widely. Here we describe a simple spectrophotometric assay for the determination of iodide accumulation in rat thyroid-derived cells ...
Fanny, Waltz +2 more
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Sodium/iodide symporter (NIS) and cytokines
Experimental and Clinical Endocrinology & Diabetes, 2001It has been shown that TSH upregulates rat NIS gene expression in vitro, and this induction can be modulated by cytokines. Analysis of the distribution of rat NIS mRNA ex vivo demonstrated variable levels of NIS transcription in different tissue samples. - IL-1beta and IL-6 have been found to decrease NIS mRNA expression in TSH-stimulated FRTL-5-cells.
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