Results 171 to 180 of about 5,659 (220)

Small‐Molecule Inhibitors of Sodium Iodide Symporter Function

ChemBioChem, 2008
Abstract The Na + /I − symporter (NIS) mediates iodide uptake into thyroid follicular cells. Although NIS has been cloned and thoroughly studied at the molecular level, the biochemical processes involved in post‐translational ...
Nathalie, Lecat-Guillet, Goulven, Merer, Roman, Lopez, Thierry, Pourcher, Bernard, Rousseau, Yves, Ambroise   +5 more
openaire   +2 more sources

Approaches to gene therapy with sodium/iodide symporter

Experimental and Clinical Endocrinology & Diabetes, 2001
Since cloning and characterization of the sodium iodide symporter (NIS) gene, several investigators explored the possibility of a novel cytoreductive gene therapy strategy based on NIS gene transfer into non-thyroidal tumor cells followed by radioiodine therapy.
C, Spitzweg, J C, Morris
openaire   +2 more sources

Reintroducing the Sodium–Iodide Symporter to Anaplastic Thyroid Carcinoma

Thyroid, 2017
Anaplastic thyroid carcinoma (ATC), the most aggressive form of thyroid cancer, is unresponsive to radioiodine therapy. The current study aimed to extend the diagnostic and therapeutic application of radioiodine beyond the treatment of differentiated thyroid cancer by targeting the functional sodium-iodide symporter (NIS) to ATC.The study employed ...
Schmohl, Kathrin A, Dolp, Patrick, Schug, Christina, Knoop, Kerstin, Klutz, Kathrin, Schwenk, Nathalie, Bartenstein, Peter, Nelson, Peter J, Ogris, Manfred, Wagner, Ernst, Spitzweg, Christine   +10 more
openaire   +3 more sources

Sodium/iodide symporter mRNA expression in cold thyroid nodules

Experimental and Clinical Endocrinology & Diabetes, 2001
Clinical and experimental data suggest a low thyroid hormone synthesis in cold thyroid nodules (CTN). Therefore, the Na(+)/I(-)-symporter (NIS) as the first step in the thyroid hormone synthesis could be a possible candidate gene in the pathogenesis of CTNs. A reduction of NIS transcripts in CTNs compared to samples of normal thyroid tissues with large
R, Paschke, S, Neumann
openaire   +2 more sources

Breast cancer brain metastases express the sodium iodide symporter

Journal of Neuro-Oncology, 2009
Breast cancer brain metastases are on the rise and their treatment is hampered by the limited entry and efficacy of anticancer drugs in this sanctuary. The sodium iodide symporter, NIS, actively transports iodide across the plasma membrane and is exploited clinically to deliver radioactive iodide into cells.
Corinne, Renier, Hannes, Vogel, Onyinye, Offor, Chen, Yao, Irene, Wapnir   +4 more
openaire   +2 more sources

Intracellular anion fluorescence assay for sodium/iodide symporter substrates

Analytical Biochemistry, 2011
The sodium/iodide symporter (NIS) is primarily responsible for iodide accumulation in the thyroid gland for the synthesis of thyroid hormones; however, it can also transport other lyotropic anions in the thyroid gland and nonthyroid tissues. Some NIS substrates have important physiological or clinical roles, and others are environmental contaminants ...
DI BERNARDO, JULIE, IOSCO, CARMELA, RHODEN, KERRY JANE   +2 more
openaire   +3 more sources

Dynamic iodide trapping by tumor cells expressing the thyroidal sodium iodide symporter

Biochemical and Biophysical Research Communications, 2004
The thyroidal sodium iodide symporter (NIS) in combination with various radioactive isotopes has shown promise as a therapeutic gene in various tumor models. Therapy depends on adequate retention of the isotope in the tumor. We hypothesized that in the absence of iodide organification, isotope trapping is a dynamic process either due to slow efflux or ...
David, Dingli, Elizabeth R, Bergert, Zeljko, Bajzer, Michael K, O'connor, Stephen J, Russell, John C, Morris   +5 more
openaire   +2 more sources

Gene therapy with sodium/iodide symporter in hepatocarcinoma

Experimental and Clinical Endocrinology & Diabetes, 2001
The ability of thyroid cells to accumulate iodide is a prerequisite for successful radioiodide therapy of benign thyroid diseases and differentiated thyroid carcinoma. The transport of iodide across the cell membrane is mediated by the sodium iodide symporter (hNIS). Employing a bicistronic retroviral vector for the transfer of the hNIS coding sequence
openaire   +2 more sources

Sodium Iodide Symporter (NIS) Gene Expression in Human Placenta

Placenta, 2001
The placenta must allow the passage of iodide from the maternal to the fetal circulation for synthesis of thyroxine by the fetal thyroid. The thyroid sodium iodide symporter (NIS) was cloned in 1996 and, although widely distributed among epithelial tissues, early studies failed to detect it in placenta. We demonstrated NIS mRNA in human placenta and in
Mitchell, AM, Manley, SW, Morris, JC, Powell, KA, Bergert, ER, Mortimer, RH   +5 more
openaire   +3 more sources

Ontogenic changes in human placental sodium iodide symporter expression

Placenta, 2012
The human fetus requires a maternal supply of iodide to synthesize thyroid hormone from 16 weeks gestation. Placental iodide transport is regulated by the sodium iodide symporter (NIS). We studied the ontogeny of NIS in placentas from surgically terminated pregnancies and from normal term pregnancies. NIS mRNA was low at 6 weeks gestation and peaked at
Li, H., Patel, J., Mortimer, R. H., Richard, K.   +3 more
openaire   +3 more sources