Extracellular vesicles deliver sodium iodide symporter protein and promote cancer cell radioiodine therapy [PDF]
Scientific Reports, 2022 Extracellular vesicles (EVs) are a promising carrier for various cargos with antitumor effects, but their capacity to transfer the ability to transport radioiodine for cancer theranostics remains unexplored.
Jin Hee Lee +3 more
doaj +2 more sources
The sodium iodide symporter: its pathophysiological and therapeutic implications [PDF]
Clinical Endocrinology, 2002 SummaryThe sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in particular lactating mammary gland. Because of its crucial role in the ability of thyroid follicular cells to trap iodide, cloning of NIS opened an exciting and ...
Christine Spitzweg, John C. Morris
openalex +3 more sources
In Vivo Myoblasts Tracking Using the Sodium Iodide Symporter Gene Expression in Dogs [PDF]
Molecular Therapy: Methods & Clinical Development, 2020 Stem cell-based therapies are a promising approach for the treatment of degenerative muscular diseases; however, clinical trials have shown inconclusive and even disappointing results so far.
Isabel Punzón +10 more
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Spatial and temporal tracking of multi-layered cells sheet using reporter gene imaging with human sodium iodide symporter: a preclinical study using a rat model of myocardial infarction. [PDF]
Eur J Nucl Med Mol ImagingOtani K +11 more
europepmc +3 more sources
The Association Between Radioiodine Refractory in Papillary Thyroid Carcinoma, Sodium/Iodide Symporter Expression, and BRAF V600E Mutation. [PDF]
Onco Targets Ther, 2021 Anekpuritanang T +5 more
europepmc +3 more sources
The master role of polarized NIS expression in regulating iodine metabolism in the human body [PDF]
Archives of Endocrinology and Metabolism, 2023 Objective: The aim of this study was to investigate how polarized sodium iodide symporter (NIS) expression may regulate iodide metabolism in vivo. Materials and methods: Polarized NIS expression was analyzed in tissues that accumulate iodide by the use ...
Bernadett Lévay +5 more
doaj +1 more source
Seaweed and Iodine Intakes and rs77277498 in Relation to Thyroid Cancer [PDF]
Endocrinology and Metabolism, 2022 Background This study aims to elucidate the associations among dietary seaweed (gim and miyeok/dashima) and iodine intakes, the rs77277498 polymorphism of the SLC5A5 gene codifying the sodium/iodine symporter, and thyroid cancer risk in a Korean ...
Tung Hoang +4 more
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Resveratrol inhibits sodium/iodide symporter gene expression and function in rat thyroid cells. [PDF]
PLoS ONE, 2014 Resveratrol is a polyphenol found in grapes and berries that has antioxidant, antiproliferative and anti-inflammatory properties. For these reasons, it is available as a dietary supplement, and it is under investigation in several clinical trials.
Cesidio Giuliani +8 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Background and ObjectivesDefects in the human sodium/iodide symporter (SLC5A5) gene have been reported to be one of the causes of congenital hypothyroidism (CH).
Cao-Xu Zhang +12 more
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Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy [PDF]
Endocrinology and Metabolism, 2019 The retained functionality of the sodium iodide symporter (NIS) expressed in differentiated thyroid cancer (DTC) cells allows the further utilization of post-surgical radioactive iodine (RAI) therapy, which is an effective treatment for reducing the risk
Jierui Liu +3 more
doaj +1 more source