Extracellular vesicles deliver sodium iodide symporter protein and promote cancer cell radioiodine therapy [PDF]
Scientific Reports, 2022 Extracellular vesicles (EVs) are a promising carrier for various cargos with antitumor effects, but their capacity to transfer the ability to transport radioiodine for cancer theranostics remains unexplored.
Jin Hee Lee +3 more
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The sodium iodide symporter: its pathophysiological and therapeutic implications [PDF]
Clinical Endocrinology, 2002 SummaryThe sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in particular lactating mammary gland. Because of its crucial role in the ability of thyroid follicular cells to trap iodide, cloning of NIS opened an exciting and ...
Christine Spitzweg, John C. Morris
openalex +4 more sources
High-Throughput Screening of ToxCast PFAS Chemical Library for Potential Inhibitors of the Human Sodium Iodide Symporter. [PDF]
Chem Res Toxicol, 2023 Over the past decade, there has been increased concern for environmental chemicals that can target various sites within the hypothalamic-pituitary-thyroid axis to potentially disrupt thyroid synthesis, transport, metabolism, and/or function.
Stoker TE +4 more
europepmc +2 more sources
Basolateral Sorting of the Sodium/Iodide Symporter Is Mediated by Adaptor Protein 1 Clathrin Adaptor Complexes. [PDF]
Thyroid, 2022 Background: The sodium/iodide symporter (NIS) is a transmembrane protein located on the basolateral membrane of thyrocytes. Despite its physiological and clinical relevance, little is known about the mechanisms that mediate NIS subcellular sorting.
Koumarianou P +5 more
europepmc +2 more sources
Stem Cells Translational Medicine, 2020 Techniques that enable longitudinal tracking of cell fate after myocardial delivery are imperative for optimizing the efficacy of cell‐based cardiac therapies.
John W. Ostrominski +20 more
doaj +2 more sources
Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma. [PDF]
Mol Ther Oncolytics, 2022 Spellerberg R +15 more
europepmc +2 more sources
Adherens Junction Integrity Is a Critical Determinant of Sodium Iodide Symporter Residency at the Plasma Membrane of Thyroid Cells. [PDF]
Cancers (Basel), 2022 Simple Summary Most cases of differentiated thyroid carcinoma (DTC) are associated with a good prognosis. However, a significant number progress to advanced disease exhibiting aggressive clinical characteristics.
Faria M +5 more
europepmc +2 more sources
Evolution and developmental expression of the sodium-iodide symporter (NIS, slc5a5) gene family: Implications for perchlorate toxicology. [PDF]
Evol Appl, 2022 The vertebrate sodium–iodide symporter (NIS or SLC5A5) transports iodide into the thyroid follicular cells that synthesize thyroid hormone. The SLC5A protein family includes transporters of vitamins, minerals, and nutrients. Disruption of SLC5A5 function
Petersen AM +9 more
europepmc +2 more sources
Transcription Factor CREB3L1 Regulates the Expression of the Sodium/Iodide Symporter (NIS) in Rat Thyroid Follicular Cells. [PDF]
Cells, 2022 The transcription factor CREB3L1 is expressed in a wide variety of tissues including cartilage, pancreas, and bone. It is located in the endoplasmic reticulum and upon stimulation is transported to the Golgi where is proteolytically cleaved.
Di Giusto P +5 more
europepmc +2 more sources
Brief Report: A Novel Sodium/Iodide Symporter Mutation, S356F, Causing Congenital Hypothyroidism. [PDF]
Thyroid, 2022 The sodium-iodide symporter (NIS, SLC5A5) is expressed at the basolateral membrane of the thyroid follicular cell, and facilitates the thyroidal iodide uptake required for thyroid hormone biosynthesis.
Durgia H +7 more
europepmc +2 more sources