Results 241 to 250 of about 22,958 (276)

The Sodium-Iodide Symporter

Current Drug Targets - Immune, Endocrine & Metabolic Disorders, 2004
The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant.
Claire H. Baker, John C. Morris
openaire   +3 more sources

Impact of the mutational landscape of the sodium/iodide symporter in congenital hypothyroidism.

Thyroid, 2021
BACKGROUND Iodide transport defect (ITD) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to homozygous or compound heterozygous pathogenic variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (NIS), causing ...
Mariano Martín, J. Nicola
semanticscholar   +1 more source

Sodium/iodide symporter in thyroid cancer

Experimental and Clinical Endocrinology & Diabetes, 2001
[No abstract available]
C. Mian, L. Lacroix, J. M. Bidart, B. Caillou, FILETTI, SEBASTIANO, M. Schlumberger   +5 more
openaire   +5 more sources

Sodium Iodide Symporter in Health and Disease

Thyroid, 2001
Radioiodine-concentrating activity in thyroid tissues has allowed the use of radioiodine as a diagnostic and therapeutic agent for patients with thyroid disorders such as well-differentiated thyroid cancer. However, some extrathyroidal tissues also take up radioiodine, contributing to unwanted side effects of radioiodine therapy.
Richard T. Kloos, Sissy M. Jhiang, Daniel H. Y. Shen, Ernest L. Mazzaferri   +3 more
openaire   +3 more sources

Cloning of the Mouse Sodium Iodide Symporter

Thyroid, 2001
The iodide-concentrating ability of the thyroid gland is essential to the production of thyroid hormone. We report the nucleotide and amino acid sequence of the mouse sodium iodide symporter (mNIS), which mediates this activity within the thyroid gland.
Charyl M. Dutton, Diana S. Dean, Lori A. Pinke, Elizabeth R. Bergert, John C. Morris, Christine Spitzweg   +5 more
openaire   +2 more sources

A novel tyrosine kinase inhibitor can augment radioactive iodine uptake through endogenous sodium/iodide symporter (NIS) expression in anaplastic thyroid cancer.

Thyroid, 2020
Background Radioactive iodine (RAI) therapy is an important strategy in the treatment of thyroid cancer. However, anaplastic thyroid cancer (ATC), a rare malignancy, exhibits severe de-differentiation characteristics along with a lack of sodium iodide ...
J. Oh, S. Baek, Prakash Gangadaran, C. Hong, R. Rajendran, H. Lee, Liya Zhu, Arunnehru Gopal, Senthilkumar Kalimuthu, S. Jeong, Sang-Woo Lee, Jaetae Lee, B. Ahn   +12 more
semanticscholar   +1 more source

Approaches to gene therapy with sodium/iodide symporter

Experimental and Clinical Endocrinology & Diabetes, 2001
Since cloning and characterization of the sodium iodide symporter (NIS) gene, several investigators explored the possibility of a novel cytoreductive gene therapy strategy based on NIS gene transfer into non-thyroidal tumor cells followed by radioiodine therapy.
John C. Morris, Christine Spitzweg
openaire   +3 more sources

Expression of the Sodium/Iodide Symporter in Human Prostate Adenocarcinoma

Urology, 2010
To analyze expression of the sodium/iodide symporter (NIS) in tissue specimen from a large series of patients with prostate adenocarcinoma. Few data are available on the NIS expression in prostate tumor tissues.NIS protein expression was examined by immunohistochemistry in 78 tumor tissue specimen and their non-neoplastic counterparts.
M. Navarra, MICALI, Salvatore, SM lepore, AM Cesinaro, M. Celano, MC Sighinolfi, C. De Gaetani, S. Filetti, BIANCHI, Giampaolo, D. Russo   +9 more
openaire   +4 more sources

A nonradioactive iodide uptake assay for sodium iodide symporter function

Analytical Biochemistry, 2010
The standard assay for sodium iodide symporter (NIS) function is based on the measurement of radioiodide uptake ((125)I) in NIS-expressing cells. However, cost and safety issues have limited the method from being used widely. Here we describe a simple spectrophotometric assay for the determination of iodide accumulation in rat thyroid-derived cells ...
Lucie Pillette, Yves Ambroise, Fanny Waltz   +2 more
openaire   +3 more sources

Sodium/iodide symporter (NIS) and cytokines

Experimental and Clinical Endocrinology & Diabetes, 2001
It has been shown that TSH upregulates rat NIS gene expression in vitro, and this induction can be modulated by cytokines. Analysis of the distribution of rat NIS mRNA ex vivo demonstrated variable levels of NIS transcription in different tissue samples. - IL-1beta and IL-6 have been found to decrease NIS mRNA expression in TSH-stimulated FRTL-5-cells.
openaire   +3 more sources