Results 251 to 260 of about 22,958 (276)

6-[124I]Iodo-9-pentylpurine for imaging the activity of the sodium iodide symporter in the brain.

Journal of Medicinal Chemistry, 2020
Iodide homeostasis and thyroid hormone metabolism in the brain are potentially related to changes in activity of the sodium iodide symporter (NIS). No radiotracers are currently available for imaging brain NIS activity.
T. Okamura, Satoshi Tsukamoto, K. Nagatsu, Maki Okada, Katsuyuki Minegishi, T. Tatsumi, Aya Sugyo, T. Kikuchi, H. Wakizaka, H. Ishii, Atsushi B. Tsuji, Ming-Rong Zhang   +11 more
semanticscholar   +1 more source

Cloning of the Human Sodium Iodide Symporter

Biochemical and Biophysical Research Communications, 1996
The iodide concentrating activity of the thyroid gland is essential to the production of thyroid hormone and also provides a mechanism for the treatment of thyroid cancer by radioiodine ablation. We report here the nucleotide and amino acid sequence of the human sodium iodide symporter (hNIS), which mediates the iodide uptake activity in the thyroid ...
Patricia A. Smanik, Sissy M. Jhiang, Shunhua Xing, Kwon-Yul Ryu, Tara L. Furminger, Qing-Rong Liu, Ernest L. Mazzaferri   +6 more
openaire   +3 more sources

Do BRAFV600E mutation and sodium-iodide symporter expression affect the response to radioactive iodine therapy in patients with papillary thyroid carcinoma?

Nuclear medicine communications, 2020
Objective To report on the associations between BRAFV600E and sodium iodide symporter expressions and treatment outcomes in patients with papillary thyroid carcinoma.
Rania M. Makboul, N. Mostafa, Heba E M El-Deek, Noha A. Aboulhagag, M. Shehata, Yasser G. Abdelhafez   +5 more
semanticscholar   +1 more source

Clinical Relevance of the Thyroid Sodium/Iodide Symporter [PDF]

, 2003
The first step in the formation of thyroid hormones (TH) involves the active accumulation of iodide from the extracellular fluid across the basolateral membrane and into the thyroid follicular cell. The protein responsible for this was previously described as the iodide trap or iodide pump.
Peter H. K. Eng, Su-Chin Ho
openaire   +1 more source

Reintroducing the Sodium–Iodide Symporter to Anaplastic Thyroid Carcinoma

Thyroid, 2017
Anaplastic thyroid carcinoma (ATC), the most aggressive form of thyroid cancer, is unresponsive to radioiodine therapy. The current study aimed to extend the diagnostic and therapeutic application of radioiodine beyond the treatment of differentiated thyroid cancer by targeting the functional sodium-iodide symporter (NIS) to ATC.The study employed ...
Peter J. Nelson, Peter Bartenstein, Ernst Wagner, Christina Schug, Patrick Dolp, Kerstin Knoop, Nathalie Schwenk, Kathrin A Schmohl, Manfred Ogris, Kathrin Klutz, Christine Spitzweg   +10 more
openaire   +4 more sources

Implications of the molecular characterization of the sodium-iodide symporter (NIS)

Experimental and Clinical Endocrinology & Diabetes, 2009
The recently cloned sodium-iodide symporter (NIS) represents a key molecule for thyroid function by efficiently accumulating iodide from the circulation into the thyrocyte against an electrochemical gradient. This uptake requires energy, is coupled to the action of Na+/K+-ATPase, and stimulated by TSH, the main hormone regulating thyroid-specific ...
Josef Köhrle, Cornelia Schmutzler
openaire   +3 more sources

Regulation of the sodium/iodide symporter by retinoids - a review

Experimental and Clinical Endocrinology & Diabetes, 2001
Decrease or loss of iodide uptake, due to impaired expression and/or function of the sodium/iodide-symporter (NIS), is a major obstacle to the treatment of advanced thyroid carcinomas by radioiodide therapy. Several approaches are being evaluated to optimise or restore sufficient iodide transport in those cases, among them retinoid therapy.
openaire   +2 more sources

Gene therapy with sodium/iodide symporter in hepatocarcinoma

Experimental and Clinical Endocrinology & Diabetes, 2001
The ability of thyroid cells to accumulate iodide is a prerequisite for successful radioiodide therapy of benign thyroid diseases and differentiated thyroid carcinoma. The transport of iodide across the cell membrane is mediated by the sodium iodide symporter (hNIS). Employing a bicistronic retroviral vector for the transfer of the hNIS coding sequence
openaire   +3 more sources

Small‐Molecule Inhibitors of Sodium Iodide Symporter Function

ChemBioChem, 2008
AbstractThe Na+/I− symporter (NIS) mediates iodide uptake into thyroid follicular cells. Although NIS has been cloned and thoroughly studied at the molecular level, the biochemical processes involved in post‐translational regulation of NIS are still unknown. The purpose of this study was to identify and characterize inhibitors of NIS function.
Roman Lopez, Nathalie Lecat-Guillet, Bernard Rousseau, Thierry Pourcher, Yves Ambroise, Goulven Merer   +5 more
openaire   +3 more sources

In vivo imaging and tumor therapy with the sodium iodide symporter

Journal of Cellular Biochemistry, 2003
AbstractThere has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non‐invasively the biodistribution, gene expression and ...
John C. Morris, Stephen J. Russell, David Dingli   +2 more
openaire   +3 more sources