Results 261 to 270 of about 22,958 (276)

Novel Sodium/Iodide Symporter Compound Heterozygous Pathogenic Variants Causing Dyshormonogenic Congenital Hypothyroidism.

Thyroid, 2019
BACKGROUND Iodide transport defect (ITD) is an autosomal recessive disorder caused by deficient iodide accumulation into the thyroid follicular cell. ITD is an uncommon cause of dyshormonogenetic congenital hypothyroidism that results from inactivating ...
Mariano Martín, Carlos Eduardo Bernal Barquero, R. C. Geysels, P. Papendieck, Victoria Peyret, A. Masini-Repiso, A. Chiesa, J. Nicola   +7 more
semanticscholar   +1 more source

Sodium Iodide Symporter in Thyroid Carcinoma

2012
Thyroid iodide uptake is essential for the clinical application of radioiodine in patients with well-differentiated thyroid carcinoma. Iodide uptake occurs across the plasma membranes of thyroid follicular cells and cancer cells via an active transporter process mediated by sodium iodide symporter (NIS).
openaire   +2 more sources

Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.

Journal of Medicinal Chemistry, 2019
An inverse agonist of estrogen-related receptor-γ (ERRγ), an orphan nuclear receptor encoded by E srrg, enhances sodium iodide symporter-mediated radioiodine uptake in anaplastic thyroid cancer (ATC) cells, thereby facilitating responsiveness to ...
Jina Kim, Jaeyoung Song, H. Ji, E. Yoo, Jae-Eon Lee, Sang Bong Lee, J. Oh, Seungmi Lee, Ji-sun Hwang, Heeseok Yoon, Dong-Su Kim, Su-Jeong Lee, Minseon Jeong, Sungwoo Lee, Kyung-Hee Kim, Hueng-Sik Choi, Sang Woo Lee, K. Park, Inkyu Lee, S. Kim, Hayoung Hwang, Y. Jeon, Jungwook Chin, S. Cho   +23 more
semanticscholar   +1 more source

Characterization of the upstream enhancer of the rat sodium/iodide symporter gene

Experimental and Clinical Endocrinology & Diabetes, 2001
We previously demonstrated the presence of an enhancer that is located between nucleotides - 2264 and - 2495 in the 5' flanking region of the rat sodium/iodide symporter (NIS) gene (Ohno et al., 1999). When attached to NIS or heterologous promoters, this 232 bp fragment, which we call NUE, is able to stimulate transcription in a thyroid-specific and ...
CHUN J. T., DI LAURO, ROBERTO
openaire   +4 more sources

A systematic evaluation of sorting motifs in the sodium–iodide symporter (NIS)

Biochemical Journal, 2016
The sodium–iodide symporter (NIS) is an integral membrane protein that plays a crucial role in iodide accumulation, especially in the thyroid. As for many other membrane proteins, its intracellular sorting and distribution have a tremendous effect on its function, and constitute an important aspect of its regulation.
Charles Marchetti, Elisabeth Darrouzet, Fanny Graslin, Iulia Tcheremisinova, Didier Marcellin, Philippe Pognonec, Philippe Pognonec, Lisa Salleron, Thierry Pourcher   +8 more
openaire   +4 more sources

Homologies of the thyroid sodium-iodide symporter with bacterial and viral proteins

Journal of Endocrinological Investigation, 1999
We have demonstrated that Na+/I- symporter (NIS), a novel thyroid autoantigen, has local amino acid sequence homologies with the other thyroid autoantigens: Thyroglobulin (Tg), thyroid peroxidase (TPO) and thyrotropin receptor (TSH-R). These homologies concern the 4th, 5th, 6th extracellular loop and the beginning of the intracellular tail.
BENVENGA, Salvatore, ALESCI S, TRIMARCHI, Francesco, FACCHIANO A.   +3 more
openaire   +5 more sources

Sodium Iodide Symporter in the Fight Against Thyroid Cancer

Future Oncology, 2013
n radioiodide n signal transduction inhibitor n sodium iodide symporter n thyroid cancer More than 60 years of experience of radioiodide therapy has indicated its usefulness for the treatment of differentiated thyroid cancer. This therapy utilizes the differentiated function of thyroid cells, namely iodide uptake for thyroid hormone synthesis.
openaire   +2 more sources

Visualisation of sodium-iodide symporter

European Journal of Nuclear Medicine and Molecular Imaging, 2005
Jordi Fuertes, Montserrat Estorch, Valle Camacho, Luis De Andres, Albert Flotats, A. J. Rodríguez, Ignasi Carrió   +6 more
openaire   +3 more sources

The sodium iodide symporter and thyroid disease

Clinical Endocrinology, 2002
Peter P.A. Smyth, Roisin M. Dwyer
openaire   +2 more sources

Regulation of sodium/iodide symporter.

Reviews in endocrine & metabolic disorders, 2000
openaire   +3 more sources