Results 21 to 30 of about 22,958 (276)

Potassium Iodide Nanoparticles Enhance Radiotherapy against Breast Cancer by Exploiting the Sodium-Iodide Symporter. [PDF]

ACS Nano, 2021
Iodine has shown promise in enhancing radiotherapy. However, conventional iodine compounds show fast clearance and low retention inside cancer cells, limiting their application as a radiosensitizer.
Cline BL, Jiang W, Lee C, Cao Z, Yang X, Zhan S, Chong H, Zhang T, Han Z, Wu X, Yao L, Wang H, Zhang W, Li Z, Xie J.   +14 more
europepmc   +2 more sources

The Association Between Radioiodine Refractory in Papillary Thyroid Carcinoma, Sodium/Iodide Symporter Expression, and BRAF ^V600E Mutation. [PDF]

Onco Targets Ther, 2021
Objective To study the association between radioiodine refractory papillary thyroid carcinoma, sodium/iodide symporter (NIS) expression, and the BRAFV600E mutation.
Anekpuritanang T, Uataya M, Claimon A, Laokulrath N, Pongsapich W, Pithuksurachai P.   +5 more
europepmc   +2 more sources

Selective sodium iodide symporter (NIS) genetherapy of glioblastoma mediatedby EGFR-targeted lipopolyplexes. [PDF]

Mol Ther Oncolytics, 2021
Spellerberg R, Benli-Hoppe T, Kitzberger C, Berger S, Schmohl KA, Schwenk N, Yen HY, Zach C, Schilling F, Weber WA, Kälin RE, Glass R, Nelson PJ, Wagner E, Spitzweg C.   +14 more
europepmc   +2 more sources

PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer [PDF]

, 2007
Background: The sodium/iodide symporter (NIS) is a membrane glycoprotein mediating active iodide uptake in the thyroid gland and is the molecular basis for radioiodide imaging and therapeutic ablation of thyroid carcinomas.
Katherine A. B. Knostman, James A. McCubrey, Carl Morrison, Zhaoxia Zhang, Charles C. Capen, Sissy Jhiang   +5 more
openalex   +5 more sources

Expanded high-throughput screening and chemotype-enrichment analysis of the phase II: e1k ToxCast library for human sodium-iodide symporter (NIS) inhibition. [PDF]

Arch Toxicol, 2021
Wang J, Richard AM, Murr AS, Buckalew AR, Lougee RR, Shobair M, Hallinger DR, Laws SC, Stoker TE.   +8 more
europepmc   +2 more sources

The master role of polarized NIS expression in regulating iodine metabolism in the human body [PDF]

Archives of Endocrinology and Metabolism, 2023
Objective: The aim of this study was to investigate how polarized sodium iodide symporter (NIS) expression may regulate iodide metabolism in vivo. Materials and methods: Polarized NIS expression was analyzed in tissues that accumulate iodide by the use ...
Bernadett Lévay, András Lantos, István Sinkovics, András Slezák, Erika Tóth, Orsolya Dohán   +5 more
doaj   +1 more source

Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS

Theranostics, 2021
The advanced, metastatic differentiated thyroid cancers (DTCs) have a poor prognosis mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of sodium iodide symporter (NIS), diminished targeting of NIS to the cell membrane,
J. Oh, B. Ahn
semanticscholar   +1 more source

Seaweed and Iodine Intakes and rs77277498 in Relation to Thyroid Cancer [PDF]

Endocrinology and Metabolism, 2022
Background This study aims to elucidate the associations among dietary seaweed (gim and miyeok/dashima) and iodine intakes, the rs77277498 polymorphism of the SLC5A5 gene codifying the sodium/iodine symporter, and thyroid cancer risk in a Korean ...
Tung Hoang, Eun Kyung Lee, Jeonghee Lee, Yul Hwangbo, Jeongseon Kim   +4 more
doaj   +1 more source

Mesenchymal Stem Cell-mediated Image-guided Sodium Iodide Symporter (NIS) Gene Therapy Improves Survival of Glioblastoma-bearing Mice.

Clinical Cancer Research, 2022
PURPOSE Mesenchymal stem cells (MSCs) have emerged as cellular-based vehicles for the delivery of therapeutic genes in cancer therapy based on their inherent tumor homing capability.
Carolin Kitzberger, Rebekka Spellerberg, Yang Han, Kathrin A Schmohl, Christina Stauss, C. Zach, R. Kälin, G. Multhoff, Mathias Eiber, F. Schilling, R. Glass, W. Weber, E. Wagner, P. Nelson, C. Spitzweg   +14 more
semanticscholar   +1 more source

Resveratrol inhibits sodium/iodide symporter gene expression and function in rat thyroid cells. [PDF]

PLoS ONE, 2014
Resveratrol is a polyphenol found in grapes and berries that has antioxidant, antiproliferative and anti-inflammatory properties. For these reasons, it is available as a dietary supplement, and it is under investigation in several clinical trials.
Cesidio Giuliani, Ines Bucci, Serena Di Santo, Cosmo Rossi, Antonino Grassadonia, Marianna Mariotti, Mauro Piantelli, Fabrizio Monaco, Giorgio Napolitano   +8 more
doaj   +1 more source