Results 21 to 30 of about 5,659 (220)

Iodine status in Turkish populations and exposure to iodide uptake inhibitors. [PDF]

PLoS ONE, 2014
Perchlorate, nitrate, and thiocyanate are competitive inhibitors of the sodium iodide symporter of the thyroid membrane. These inhibitors can decrease iodine uptake by the symporter into the thyroid gland and may disrupt thyroid function.
Aysel Ozpinar, Fahrettin Kelestimur, Yildiran Songur, Ozge Can, Liza Valentin, Kathleen Caldwell, Ender Arikan, Ibrahim Unsal, Mustafa Serteser, Tamer Inal, Yigit Erdemgil, Abdurrahman Coskun, Nadi Bakirci, Ozlem Sezgin, Ben Blount   +14 more
doaj   +1 more source

Anion Selectivity by the Sodium Iodide Symporter [PDF]

Endocrinology, 2003
Abstract The iodide transporter of the thyroid (NIS) has been cloned by the group of Carrasco. The NIS-mediated transport was studied by electrophysiological methods in NIS-expressing Xenopus oocytes. Using this method, the anion selectivity of NIS was different from that previously reported for thyroid cells, whereas perchlorate and ...
Van Sande, Jacqueline, Massart, Claude, Beauwens, Renaud, Schoutens, André, Costagliola, Sabine, Dumont, Jacques Emile, Wolff, J   +6 more
openaire   +2 more sources

Reporter gene-engineering of human induced pluripotent stem cells during differentiation renders in vivo traceable hepatocyte-like cells accessible

Stem Cell Research, 2019
Primary hepatocyte transplantation (HTx) is a safe cell therapy for patients with liver disease, but wider application is circumvented by poor cell engraftment due to limitations in hepatocyte quality and transplantation strategies. Hepatocyte-like cells
Candice Ashmore-Harris, Samuel JI Blackford, Benjamin Grimsdell, Ewelina Kurtys, Marlies C Glatz, Tamir S Rashid, Gilbert O Fruhwirth   +6 more
doaj   +1 more source

Radioiodine Therapy in Differentiated Thyroid Cancer: The First Targeted Therapy in Oncology [PDF]

Endocrinology and Metabolism, 2014
Iodide uptake across the membranes of thyroid follicular cells and cancer cells occurs through an active transport process mediated by the sodium-iodide symporter (NIS). The rat and human NIS-coding genes were cloned and identified in 1996. Evaluation of
June-Key Chung, Gi Jeong Cheon
doaj   +1 more source

Palmitic Acid Downregulates Thyroglobulin (Tg), Sodium Iodide Symporter (NIS), and Thyroperoxidase (TPO) in Human Primary Thyrocytes: A Potential Mechanism by Which Lipotoxicity Affects Thyroid?

International Journal of Endocrinology, 2018
Our previous studies suggested that the thyroid might be a target organ affected by lipotoxicity, which might be partially related to the increasing prevalence of subclinical hypothyroidism.
Meng Zhao, Xiaohan Zhang, Ling Gao, Yongfeng Song, Chao Xu, Chunxiao Yu, Shanshan Shao, Jiajun Zhao   +7 more
doaj   +1 more source

Sodium Iodide Symporter (NIS) and Thyroid

HORMONES, 2002
idase (TPO) and incorporation into tyrosyl residues along the thyroglobulin (Tg) backbone. The thyroid hormones T3 and T4 are synthesized by coupling of two iodotyrosine residues and stored in the colloid. All of these steps are stimulated by pituitary-derived thyroid stimulating hormone (TSH), which interacts with the TSH receptor at the basolateral ...
Christine, Spitzweg, John C, Morris
openaire   +2 more sources

Unilateral breast uptake of Tc-99m pertechnetate in a patient with cold nodule of the thyroid

World Journal of Nuclear Medicine, 2012
Common causes of unilateral breast uptake of Tc-99m pertechnetate are predominant breast-feeding on one side, mastitis, and breast cancer. Uptake of Tc-99m pertechnetate in the epithelial cells of the breast, like that of iodide, depends on the ...
Shankaramurthy Gayana, Anish Bhattacharya, Koramadai Kamaleshwaran, Bhagwant Mittal   +3 more
doaj   +1 more source

Modulation of Sodium Iodide Symporter in Thyroid Cancer [PDF]

Hormones and Cancer, 2014
Radioactive iodine (RAI) is a key therapeutic modality for thyroid cancer. Loss of RAI uptake in thyroid cancer inversely correlates with patient's survival. In this review, we focus on the challenges encountered in delivering sufficient doses of I-131 to eradicate metastatic lesions without increasing the risk of unwanted side effects.
Aparna, Lakshmanan, Daniel, Scarberry, Daniel H, Shen, Sissy M, Jhiang   +3 more
openaire   +2 more sources

Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells

Nature Communications, 2018
Adoptive transfer of chimeric antigen receptor (CAR) T cells has shown promising anticancer results in clinical trials. Here the authors use the human sodium iodide symporter (hNIS) as a reporter gene to image human CAR T cells in cancer-bearing mice ...
Nia Emami-Shahri, Julie Foster, Roxana Kashani, Patrycja Gazinska, Celia Cook, Jane Sosabowski, John Maher, Sophie Papa   +7 more
doaj   +1 more source

Homology of pendrin sodium-iodide symporter and apical iodide transporter

Frontiers in Bioscience, 2018
We observed local homology between human pendrin and sodium/iodide symporter (NIS), that was absent in the NIS-homologous sodium/monocarboxylate transporter or apical iodide transporter (AIT) which, however, does not transport iodide. Thus, we analyzed the full proteins.
Benvenga, Salvatore, Guarneri, Fabrizio
openaire   +3 more sources