Results 31 to 40 of about 5,659 (220)

MAPK Inhibitors Enhance HDAC Inhibitor-Induced Redifferentiation in Papillary Thyroid Cancer Cells Harboring BRAFV600E: An In Vitro Study

Molecular Therapy: Oncolytics, 2019
Clinical efficacy of redifferentiation therapy with histone deacetylase inhibitor (HDACi) for lethal radioiodine-refractory papillary thyroid cancer (RR-PTC) is urgently needed to be improved.
Hao Fu, Lingxiao Cheng, Yuchen Jin, Lin Cheng, Min Liu, Libo Chen   +5 more
doaj   +1 more source

Evidence of the Presence of Thyroid Hormones in Achatina fulica Snails

Anais da Academia Brasileira de Ciências
The objective of this study was to identify thyroid hormones and to examine their putative site of synthesis in Achatina fulica snails. For this purpose, radioimmunoassays were performed for T3 and T4 before and after long starvation with or without ...
DANILO LUSTRINO, ALBA C.M. SILVA, IRACEMA G. ARAUJO, VICTOR M. TUNHOLI, VINÍCIUS M. TUNHOLI-ALVES, ROSANE N. CASTRO, DENISE P. CARVALHO, JAIRO PINHEIRO, MICHELLE P. MARASSI   +8 more
doaj   +1 more source

A Novel Chimeric Poxvirus Encoding hNIS Is Tumor-Tropic, Imageable, and Synergistic with Radioiodine to Sustain Colon Cancer Regression

Molecular Therapy: Oncolytics, 2019
Colon cancer has a high rate of recurrence even with good response to modern therapies. Novel curative adjuncts are needed. Oncolytic viral therapy has shown preclinical promise against colon cancer but lacks robust efficacy in clinical trials and raises
Susanne G. Warner, Sang-In Kim, Shyambabu Chaurasiya, Michael P. O’Leary, Jianming Lu, Venkatesh Sivanandam, Yanghee Woo, Nanhai G. Chen, Yuman Fong   +8 more
doaj   +1 more source

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition

Environment International, 2019
In support of the Endocrine Disruptor Screening Program (EDSP), the U.S.EPA's Office of Research and Development (ORD) is developing high-throughput screening (HTS) approaches to identify chemicals that alter target sites in the thyroid hormone (TH ...
Jun Wang, Daniel R. Hallinger, Ashley S. Murr, Angela R. Buckalew, Ryan R. Lougee, Ann M. Richard, Susan C. Laws, Tammy E. Stoker   +7 more
doaj   +1 more source

Expression of the sodium iodide symporter in human kidney [PDF]

Kidney International, 2001
The human sodium iodide symporter (hNIS) is a transmembrane protein that mediates the active transport of iodide in the thyroid gland. Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein.The aim of ...
Spitzweg, Christine, Dutton, Charyl M., Castro, Maria R., Bergert, Elizabeth R., Goellner, John R., Heufelder, Armin E., Morris, John C.   +6 more
openaire   +2 more sources

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source

Real-time imaging of myoblast transplantation using the human sodium iodide symporter

BioTechniques, 2005
The quantification of the graft success is a key element to evaluate the efficiency of cellular therapies for several pathologies such as Duchenne muscular dystrophy. This study describes an approach to evaluate the success of myoblast transplantation (i.
Manaf Bouchentouf, Basma F. Benabdallah, Marcel Dumont, Joel Rousseau, Luc Jobin, Jacques P. Tremblay   +5 more
doaj   +1 more source

Perchlorate, nitrate, and thiocyanate: Environmental relevant NIS-inhibitors pollutants and their impact on thyroid function and human health

Frontiers in Endocrinology, 2022
Thyroid disruptors are found in food, atmosphere, soil, and water. These contaminants interfere with the thyroid function through the impairment of thyroid hormone synthesis, plasma transport, peripheral metabolism, transport into the target cells, and ...
Caroline Serrano-Nascimento, Caroline Serrano-Nascimento, Maria Tereza Nunes   +2 more
doaj   +1 more source

Rat Sodium Iodide Symporter for Radioiodide Therapy of Cancer [PDF]

Clinical Cancer Research, 2004
Abstract Design and development of new approaches for targeted radiotherapy of cancer and improvement of therapeutic index by more local radiation therapy are very important issues. Adenovirus-mediated delivery of the sodium iodide symporter (NIS) gene to cancer cells is a powerful technique to concentrate lethal radiation in tumor cells
Elena, Mitrofanova, Robert, Unfer, Nick, Vahanian, Wayne, Daniels, Erica, Roberson, Tatiana, Seregina, Prem, Seth, Charles, Link   +7 more
openaire   +2 more sources