Anion Selectivity by the Sodium Iodide Symporter [PDF]
Endocrinology, 2003 Abstract The iodide transporter of the thyroid (NIS) has been cloned by the group of Carrasco. The NIS-mediated transport was studied by electrophysiological methods in NIS-expressing Xenopus oocytes. Using this method, the anion selectivity of NIS was different from that previously reported for thyroid cells, whereas perchlorate and ...
Van Sande, Jacqueline +6 more
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Frontiers in Endocrinology, 2021 Background and ObjectivesDefects in the human sodium/iodide symporter (SLC5A5) gene have been reported to be one of the causes of congenital hypothyroidism (CH).
Cao-Xu Zhang +12 more
doaj +1 more source
The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment.
Endocrine-Related Cancer, 2021 Cloning of the sodium iodide symporter (NIS) 25 years ago has opened an exciting chapter in molecular thyroidology with the characterization of NIS as one of the most powerful theranostic genes and the development of a promising gene therapy strategy ...
C. Spitzweg +7 more
semanticscholar +1 more source
Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy [PDF]
Endocrinology and Metabolism, 2019 The retained functionality of the sodium iodide symporter (NIS) expressed in differentiated thyroid cancer (DTC) cells allows the further utilization of post-surgical radioactive iodine (RAI) therapy, which is an effective treatment for reducing the risk
Jierui Liu +3 more
doaj +1 more source
Expression of the sodium iodide symporter in human kidney [PDF]
Kidney International, 2001 The human sodium iodide symporter (hNIS) is a transmembrane protein that mediates the active transport of iodide in the thyroid gland. Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein.The aim of ...
Charyl M. Dutton +6 more
openaire +3 more sources
Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter.
Cell Chem Biol, 2022 Read ML +14 more
europepmc +2 more sources
Thyroid, 2021 BACKGROUND The Hippo pathway has a fundamental role in tissue homeostasis, but little is known about how this signaling cascade is controlled in the thyroid.
C. Fernández-Méndez, P. Santisteban
semanticscholar +1 more source
Iodine status in Turkish populations and exposure to iodide uptake inhibitors. [PDF]
PLoS ONE, 2014 Perchlorate, nitrate, and thiocyanate are competitive inhibitors of the sodium iodide symporter of the thyroid membrane. These inhibitors can decrease iodine uptake by the symporter into the thyroid gland and may disrupt thyroid function.
Aysel Ozpinar +14 more
doaj +1 more source
Distribution and dynamics of Tc-99m-pertechnetate uptake in the thyroid and other organs assessed by single-photon emission computed tomography in living mice [PDF]
, 2010 Background: Tc-99m pertechnetate is a well-known anion, used for clinical imaging of thyroid function. This gamma emitter is transported by the sodium iodide symporter but is not incorporated into thyroglobulin. Scintigraphy using Tc-99m pertechnetate or
Darcourt, Jacques +6 more
core +1 more source
TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells. [PDF]
PLoS One, 2020 The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. NIS expression in thyroid cancer (TC) cells allows the use of radioactive iodine (RAI) as a diagnostic and therapeutic tool, being RAI ...
Faria M +5 more
europepmc +2 more sources