Advances in the design and development of oncolytic measles viruses. [PDF]
, 2015 A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian +2 more
core +1 more source
Frontiers in Oncology, 2021 The dedifferentiation of differentiated thyroid cancer (DTC) is a challenging problem for radioactive iodine (131I) treatment, also known as radioiodine refractory differentiated thyroid cancer (RAIR-DTC). The purpose of this study was to further explore
Shasha Hou +7 more
semanticscholar +1 more source
Modulation of Sodium Iodide Symporter in Thyroid Cancer [PDF]
Hormones and Cancer, 2014 Radioactive iodine (RAI) is a key therapeutic modality for thyroid cancer. Loss of RAI uptake in thyroid cancer inversely correlates with patient's survival. In this review, we focus on the challenges encountered in delivering sufficient doses of I-131 to eradicate metastatic lesions without increasing the risk of unwanted side effects.
Daniel Scarberry +3 more
openaire +3 more sources
Genetic Factors That Might Lead to Different Responses in Individuals Exposed to Perchlorate [PDF]
, 2005 Perchlorate has been detected in groundwater in many parts of the United States, and recent detection in vegetable and dairy food products indicates that contamination by perchlorate is more widespread than previously thought.
Fowler, Bruce A. +4 more
core +2 more sources
Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma. [PDF]
Sci Rep, 2020 Anaplastic thyroid carcinoma (ATC) is the most rare and lethal form of thyroid cancer and requires effective treatment. Efforts have been made to restore sodium-iodide symporter (NIS) expression in ATC cells where it has been downregulated, yet without ...
Rakhsh-Khorshid H +7 more
europepmc +2 more sources
Functional characterization of human thyroid tissue with immunohistochemistry [PDF]
, 2007 Immunohistochemistry provides insights in the expression of functional proteins and of their localization in normal thyroid tissue and in thyroid diseases.
Bernard, Caillou +6 more
core +1 more source
Mapping of Ion and Substrate Binding Sites in Human Sodium Iodide Symporter (hNIS). [PDF]
J Chem Inf Model, 2020 The human sodium iodide symporter (hNIS) is a theranostic reporter gene which concentrates several clinically approved SPECT and PET radiotracers and plays an essential role for the synthesis of thyroid hormones as an iodide transporter in the thyroid ...
Zhekova HR +10 more
europepmc +2 more sources
S-nitrosylation of NF-kB p65 inhibits TSH-induced Na+/I- symporter expression [PDF]
, 2015 Nitric oxide (NO) is a ubiquitous signaling molecule involved in a wide variety of cellular physiological processes. In thyroid cells, NO-synthase III-endogenously produced NO reduces thyrotropin (TSH)-stimulated thyroid specific gene expression ...
Bocco, Jose Luis +8 more
core +3 more sources
Characterization of the Sodium Iodide Symporter Binding Sites [PDF]
Biophysical Journal, 2015 Sodium iodide symporter (NIS) is a membrane protein responsible for accumulation of iodide (I-) in the thyroid and other organs. This is accomplished through active transports in which the sodium (Na+) gradient provides the driving force. In our approach we attempt to bring together the most recent finding on the NIS homologous systems and shine light ...
Sergei Y. Noskov +3 more
openaire +2 more sources
Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS). [PDF]
PLoS One, 2020 The sodium iodide symporter (NIS) transports iodide, which is necessary for thyroid hormone production. NIS also transports other monovalent anions such as tetrafluoroborate (BF4-), pertechnetate (TcO4-), and thiocyanate (SCN-), and is competitively ...
Concilio SC +3 more
europepmc +2 more sources