Results 41 to 50 of about 5,659 (220)
FEBS Letters, Volume 600, Issue 2, Page 215-225, January 2026.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Majalah Kedokteran AndalasAbstrak Tujuan: Mengetahui hubungan ekspresi sodium iodide symporter dengan varian histopatologi dan stadium papillary thyroid carcinoma.
Rini Purnama Sari +5 more
doaj +1 more source
Regulation of the sodium iodide symporter by iodide in FRTL-5 cells [PDF]
European Journal of Endocrinology, 2001 OBJECTIVE: The acute decrease in iodide organification in the thyroid in response to excess iodide is termed the acute Wolff-Chaikoff effect and normal organification resumes in spite of continued high plasma iodide concentrations (escape from the acute Wolff-Chaikoff effect).
P H, Eng +4 more
openaire +2 more sources
ChemBioChem, Volume 27, Issue 1, January 2026.Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh +7 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2014 Background/Aims: Iodide efflux from thyroid cells into the follicular lumen is essential for the synthesis of thyroid hormones, however, the pathways mediating this transport have only been partially identified.
Carmela Iosco +10 more
doaj +1 more source
Medicinal Research Reviews, Volume 46, Issue 1, Page 203-237, January 2026.ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller +5 more
wiley +1 more source
Differentiated thyroid cancer: Growth factors, oncogenes and environmental influences [PDF]
Archive of Oncology, 2003 The present data of growth factors, oncogenes, tumor-suppressor-genes and environmental factors can be summarized in thus: thyrotropin, growth factors and other hormones do increase thyrocyte growth and specific mutations of growth factor receptors ...
Paunović Ivan R.
doaj +1 more source
SPE Polymers, Volume 7, Issue 1, January 2026.Development of high‐filler‐content silicone rubber composites containing up to 80 wt% bismuth oxide or copper, demonstrating significant I‐131 attenuation with retained flexibility and durability. ABSTRACT The development of flexible, non‐lead radiation‐shielding materials remains a critical challenge, particularly for I‐131 protection, where no ...
Kanaungnit Kingpetch +3 more
wiley +1 more source
Glycosylation of Sodium/Iodide Symporter (NIS) Regulates Its Membrane Translocation and Radioiodine Uptake. [PDF]
PLoS ONE, 2015 Human sodium/iodide symporter (hNIS) protein is a membrane glycoprotein that transports iodide ions into thyroid cells. The function of this membrane protein is closely regulated by post-translational glycosylation.
Taemoon Chung +4 more
doaj +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets
British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +51 more
wiley +1 more source