Results 61 to 70 of about 22,958 (276)

The Sodium-Iodide Symporter NIS and Pendrin in Iodide Homeostasis of the Thyroid [PDF]

Endocrinology, 2009
Thyroid hormones are essential for normal development and metabolism. Thyroid hormone biosynthesis requires iodide uptake into the thyrocytes and efflux into the follicular lumen, where it is organified on selected tyrosyls of thyroglobulin. Uptake of iodide into the thyrocytes is mediated by an intrinsic membrane glycoprotein, the sodium-iodide ...
Peter Kopp, Aigerim Bizhanova
openaire   +3 more sources

Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells

Nature Communications, 2018
Adoptive transfer of chimeric antigen receptor (CAR) T cells has shown promising anticancer results in clinical trials. Here the authors use the human sodium iodide symporter (hNIS) as a reporter gene to image human CAR T cells in cancer-bearing mice ...
Nia Emami-Shahri, Julie Foster, Roxana Kashani, Patrycja Gazinska, Celia Cook, Jane Sosabowski, John Maher, Sophie Papa   +7 more
doaj   +1 more source

Homology of pendrin sodium-iodide symporter and apical iodide transporter

Frontiers in Bioscience, 2018
We observed local homology between human pendrin and sodium/iodide symporter (NIS), that was absent in the NIS-homologous sodium/monocarboxylate transporter or apical iodide transporter (AIT) which, however, does not transport iodide. Thus, we analyzed the full proteins.
Benvenga, Salvatore, Guarneri, Fabrizio
openaire   +4 more sources

Fibronectin-1 expression is increased in aggressive thyroid cancer and favors the migration and invasion of cancer cells [PDF]

, 2016
n this study we analyzed the expression levels of markers of epithelial-to-mesenchymal transition (EMT) in several papillary thyroid carcinomas (PTCs) and the relation with tumor genotypes and clinicopathological characteristics.
Bulotta, Stefania, Celano, Marilena, Damante, Giuseppe, De Rose, Roberta Francesca, DURANTE, COSIMO, FILETTI, SEBASTIANO, Lombardo, Giovanni Enrico, Maggisano, Valentina, PECCE, VALERIA, ROSIGNOLO, FRANCESCA, Russo, Diego, SPONZIELLO, Marialuisa   +11 more
core   +1 more source

HSV-NIS, an oncolytic herpes simplex virus type 1 encoding human sodium iodide symporter for preclinical prostate cancer radiovirotherapy [PDF]

, 2014
Several clinical trials have shown that oncolytic herpes simplex virus type 1 (oHSV-1) can be safely administered to patients. However, virus replication in tumor tissue has generally not been monitored in these oHSV clinical trials, and the data suggest
Decklever, T D, Li, H, Nace, R A, Nakashima, H, Russell, S J   +4 more
core   +1 more source

Re-visiting autoimmunity to sodium-iodide symporter and pendrin in thyroid disease.

European Journal of Endocrinology, 2020
Objective Iodide transport across thyrocytes constitutes a critical step for thyroid hormone biosynthesis, mediated mainly by the basolateral sodium-iodide-symporter (NIS (SLC5A5)) and the apical anion exchanger pendrin (PDS (SLC26A4)).
A. Eleftheriadou, S. Mehl, K. Renko, Rega H. Kasim, Jasmin Schaefer, W. Minich, L. Schomburg   +6 more
semanticscholar   +1 more source

Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells [PDF]

, 2015
The aetiology of human fibrolamellar hepatocellular carcinomas (hFL-HCCs), cancers occurring increasingly in children to young adults, is poorly understood.
ALVARO, Domenico, CARDINALE, VINCENZO, Carpino, Guido, Carrasco, Nancy, Dinh, Timothy A., GAUDIO, EUGENIO, Klimstra, David, Levine, Ronald, Oikawa, Tsunekazu, Reid, Lola M., Reyna Neyra, Andrea, Selitsky, Sara R., Sethupathy, Praveen, Wauthier, Eliane   +13 more
core   +2 more sources

Evidence of the Presence of Thyroid Hormones in Achatina fulica Snails

Anais da Academia Brasileira de Ciências
The objective of this study was to identify thyroid hormones and to examine their putative site of synthesis in Achatina fulica snails. For this purpose, radioimmunoassays were performed for T3 and T4 before and after long starvation with or without ...
DANILO LUSTRINO, ALBA C.M. SILVA, IRACEMA G. ARAUJO, VICTOR M. TUNHOLI, VINÍCIUS M. TUNHOLI-ALVES, ROSANE N. CASTRO, DENISE P. CARVALHO, JAIRO PINHEIRO, MICHELLE P. MARASSI   +8 more
doaj   +1 more source

Effective control of tumor growth through spatial and temporal control of theranostic sodium iodide symporter (NIS) gene expression using a heat-inducible gene promoter in engineered mesenchymal stem cells

Theranostics, 2020
Purpose: The tumor homing characteristics of mesenchymal stem cells (MSCs) make them attractive vehicles for the tumor-specific delivery of therapeutic agents, such as the sodium iodide symporter (NIS).
Mariella Tutter, C. Schug, Kathrin A Schmohl, Sarah Urnauer, Nathalie Schwenk, M. Petrini, W. Lokerse, C. Zach, S. Ziegler, P. Bartenstein, W. Weber, E. Wagner, L. Lindner, P. Nelson, C. Spitzweg   +14 more
semanticscholar   +1 more source

The extra-thyroidal distribution of sodium iodide symporter

Frontiers in Endocrinology
The intrinsic transmembrane protein known as sodium iodide symporter (NIS) facilitates the active transport of iodide across the basolateral membrane of thyroid follicular cells.
Rinae Prisca Gadisi, Meleshni Naicker, Strinivasen Naidoo   +2 more
doaj   +1 more source