Results 61 to 70 of about 5,659 (220)

Molecular In Vivo Imaging Using a Noninvasive Cardiac-Specific MLC-2v Promoter Driven Dual-Gene Recombinant Lentivirus Monitoring System. [PDF]

PLoS ONE, 2015
Our study aimed to demonstrate the feasibility of using the sodium/iodide symporter (NIS) to monitor vascular endothelial growth factor (VEGF165) expression in vivo.We constructed a recombinant lentivirus plasmid with the MLC-2v promoter driving the ...
Miao Zhang, Lihua Wang, Rui Guo, Sheng Liang, Xufeng Jiang, Min Zhang, Biao Li   +6 more
doaj   +1 more source

Modular breast and tumor perfusion phantoms for 4D dynamic contrast‐enhanced dedicated breast CT

Medical Physics, Volume 52, Issue 10, October 2025.
Abstract Background Tumor heterogeneity presents significant challenges in breast cancer diagnosis and treatment. Four‐dimensional dynamic contrast‐enhanced dedicated breast CT (4D DCE‐bCT) is a novel imaging technique designed to capture contrast agent kinetics with high spatial and temporal resolution, enabling detailed assessment of tumor perfusion ...
Liselot C. Goris, Sanne Gouma, Juan J. Pautasso, Koen Michielsen, Ioannis Sechopoulos   +4 more
wiley   +1 more source

CRISPR/Cas9‐mediated introduction of the sodium/iodide symporter gene enables noninvasive in vivo tracking of induced pluripotent stem cell‐derived cardiomyocytes

Stem Cells Translational Medicine, 2020
Techniques that enable longitudinal tracking of cell fate after myocardial delivery are imperative for optimizing the efficacy of cell‐based cardiac therapies.
John W. Ostrominski, Ravi Chandra Yada, Noriko Sato, Michael Klein, Ksenia Blinova, Dakshesh Patel, Racquel Valadez, Maryknoll Palisoc, Stefania Pittaluga, Kah‐Whye Peng, Hong San, Yongshun Lin, Falguni Basuli, Xiang Zhang, Rolf E. Swenson, Mark Haigney, Peter L. Choyke, Jizhong Zou, Manfred Boehm, So Gun Hong, Cynthia E. Dunbar   +20 more
doaj   +1 more source

Construction of a Fluorescence‐Based Logic Gate Seeing the Effect of Perchlorate Ions on Hemicyanine Dye–β‐Cyclodextrin Complexes to Certify Safe Drinking Water

ChemistryOpen, Volume 14, Issue 10, October 2025.
A method to detect perchlorate ions and certify safe drinking water by constructing a fluorescence‐based logic gate considering the binding of a hemicyanine dye with β‐CD is presented. Perchlorate ions (ClO4−) are prevalent contaminants in the surface, and drinking water that disrupt thyroid function by competitively inhibiting the sodium‐iodide ...
Anusha C. M., Shalini Dyagala, Sairathna Choppella, Mahesh Kumar Ravva, Subit Kumar Saha   +4 more
wiley   +1 more source

Sodium-Iodide Symporter Mediates Iodide Secretion in Rat Gastric Mucosa In Vitro

Experimental Biology and Medicine, 2006
In vivo studies on rats have demonstrated that considerable amounts of iodide are transported from the bloodstream into the gastric lumen. The mechanisms for and functional significance of this transport are poorly understood. Active (driven by Na+/K+-ATPase) iodide transport into thyroid follicular cells is mediated by the sodium-iodide symporter (NIS)
Malin, Josefsson, Lena, Evilevitch, Björn, Weström, Torsten, Grunditz, Eva, Ekblad   +4 more
openaire   +2 more sources

Revisionist history uncovers a simplified molecular‐based classification of differentiated thyroid cancer

The Journal of Pathology, Volume 267, Issue 2, Page 130-141, October 2025.
Abstract The diagnostic classification of differentiated thyroid cancer has been a longstanding topic of debate among pathologists, largely due to high interobserver variability. This complexity has increased with the expansion of tumor types and subtypes.
Sylvia L Asa, Zubair Baloch, Chan Kwon Jung, Nicole A Cipriani, Armando Gamboa‐Domínguez, C Christofer Juhlin, Nicole D Riddle, Ivan J Stojanov, Ozgur Mete   +8 more
wiley   +1 more source

Sodium Iodide Symporter and Phosphatase and Tensin Homolog Deleted on Chromosome Ten Expression in Cholangiocarcinoma Analysis with Clinicopathological Parameters

Gut and Liver, 2012
Background/AimsThis study was performed to investigate the correlation of sodium iodide symporter (NIS) expression with the functionality and loss of phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression in human cholangiocarcinoma ...
doaj   +1 more source

Tracking dendritic cell migration into lymph nodes by using a novel PET probe 18F-tetrafluoroborate for sodium/iodide symporter

EJNMMI Research, 2017
Background Recently, 18F-tetrafluoroborate (TFB) was used as a substrate for the human sodium/iodide symporter (hNIS) reporter gene. This study evaluated the feasibility of performing molecular-genetic imaging by using the new radiotracer (18F-TFB) for ...
Sang Bong Lee, Ho Won Lee, Hongje Lee, Yong Hyun Jeon, Sang-Woo Lee, Byeong-Cheol Ahn, Jaetae Lee, Shin Young Jeong   +7 more
doaj   +1 more source

Structural insights into the mechanism of the sodium/iodide symporter (NIS) [PDF]

, 2022
Silvia Ravera, Juan P. Nicola, Glicella Salazar-De Simone, Fred J. Sigworth, Erkan Karakaş, L. Mario Amzel, Mario A. Bianchet, Nancy Carrasco   +7 more
openalex   +1 more source

Development and characterisation of improved unifocal primary mouse lung cancer models with metastatic potential

The Journal of Pathology, Volume 266, Issue 4-5, Page 405-420, August 2025.
Abstract Lung cancer is the leading cause of cancer‐related death globally. To better understand the biology of lung cancer, mouse models have been developed using either tail vein‐injected tumour cell lines or genetically modified mice. The current gold‐standard models typically present with multiple lung foci.
Ana‐Rita Pedrosa, Alejandro Castillo‐Kauil, Yuliia Kravchuk, Louise Reynolds, Bruce Williams, David Moore, Cameron Lang, Srinivas Allanki, Eleni Maniati, Alexandros Hardas, Jozafina Haj, Rebecca Drake, Julie Cleaver, Julie Foster, Jana Kim, Ester Stern, Jane Sosabowski, Gilbert O. Fruhwirth, Erik Sahai, Ori Wald, Kairbaan Hodivala‐Dilke   +20 more
wiley   +1 more source