Results 71 to 80 of about 22,958 (276)

Modulation of Sodium/Iodide Symporter Expression in the Salivary Gland [PDF]

Thyroid, 2013
Physiologic iodide-uptake, mediated by the sodium/iodide symporter (NIS), in the salivary gland confers its susceptibility to radioactive iodine-induced damage following (131)I treatment of thyroid cancer. Subsequent quality of life for thyroid cancer survivors can be decreased due to recurrent sialoadenitis and persistent xerostomia. NIS expression at
Adam Bobbey, Nathan Hall, Rebecca Nagy, Amy Lehman, Paul E. Wakely, Sissy M. Jhiang, Krista M. D. La Perle, David Jarjoura, Daniel H. Shen, Dong Chul Kim   +9 more
openaire   +3 more sources

Goiter frequency is more strongly associated with gastric adenocarcinoma than urine iodine level [PDF]

, 2013
Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune ...
Adabi, K., Haghpanah, V., Hatami, E., Heshmat, R., Jahangirrad, A., Keshtkar, A., Kia, A., Larijani, B., Nabizadeh, R., Rohani, D., Roshandel, G., Semnani, S., Tabaeizadeh, M.   +12 more
core   +1 more source

Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer

Frontiers in Oncology, 2020
Nevirapine has been proved to be effective in inducing re-differentiation and suppressing tumor growth in several tumor cells. This study aims to investigate the therapeutic potential of nevirapine in dedifferentiated thyroid cancer (DeTC), which ...
H. Shang, Jun-yu Zhao, Jin-ming Yao, Huanjun Wang, Jianjun Dong, L. Liao   +5 more
semanticscholar   +1 more source

A Critical Overview of Common Foodborne Toxicants and Methods for Their Reliable Detection

Food Frontiers, EarlyView.
ABSTRACT Food is an essential commodity for human health. However, toxicants such as mycotoxins, heavy metals, acrylamide, and pesticides can be present in food either naturally or through processing, packaging, or some anthropogenic activities. A thorough review of carefully selected studies revealed that climate change and pandemics have led to an ...
Betty Bowe Acquah, John‐Lewis Zinia Zaukuu   +1 more
wiley   +1 more source

Relationship between PI3K Mutation and Sodium-Iodide Symporter in Anaplastic Thyroid Carcinoma [PDF]

, 2015
The sodium-iodide symporter is a transmembrane protein that has important role in radio-iodide therapy in various cancers such as anaplastic thyroid carcinoma.
Bozorg-Ghalati, Farzaneh, Hedayati, Mehdi   +1 more
core  

A role for the small GTPases RAC1 and RAC1b in the modulation of NIS expression: potentiation of therapy with radioactive iodine in differentiated thyroid carcinoma [PDF]

, 2019
Introduction or Background: The Sodium Iodide Symporter (NIS) is responsible for active transport of iodide into thyroid follicular cells. The retention of its functional expression in most of the well-differentiated thyroid carcinomas (DTCs) enables ...
Bugalho, Maria J., Domingues, Rita, Faria, Márcia, Félix, Daniela, Matos, Paulo, Silva, Ana L.   +5 more
core   +1 more source

Combination of peroxisome proliferator–activated receptor gamma and retinoid X receptor agonists induces sodium/iodide symporter expression and inhibits cell growth of human thyroid cancer cells

Journal of the Chinese Medical Association, 2020
Background: Thyroid tumors are the most frequent neoplasm of the endocrine system. The major treatment is surgical intervention followed by radioiodine therapy.
Jui-Yu Chen, Jane-Jen Wang, Hsin-Chen Lee, C. Chi, Chen-hsen Lee, Yi-Chiung Hsu   +5 more
semanticscholar   +1 more source

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source

Effect of Mutations on Transport by the Sodium/Iodide Symporter (NIS) [PDF]

Biophysical Journal, 2015
The Na+/I- symporter (NIS) mediates iodide transport into the thyroid and other tissues, such as salivary glands, stomach, lactating breast, and small intestine. To understand the observed effects of single amino acid substitutions in the mechanism of transport by NIS, wild type NIS and NIS mutated at selected positions were studied using computational
L. Mario Amzel, Yuly E. Sánchez, Yuly E. Sánchez, Juan Pablo Nicola, Giuseppe Ferrandino, Nancy Carrasco   +5 more
openaire   +2 more sources

Construction of a Fluorescence‐Based Logic Gate Seeing the Effect of Perchlorate Ions on Hemicyanine Dye–β‐Cyclodextrin Complexes to Certify Safe Drinking Water

ChemistryOpen, EarlyView.
A method to detect perchlorate ions and certify safe drinking water by constructing a fluorescence‐based logic gate considering the binding of a hemicyanine dye with β‐CD is presented. Perchlorate ions (ClO4−) are prevalent contaminants in the surface, and drinking water that disrupt thyroid function by competitively inhibiting the sodium‐iodide ...
Anusha C. M., Shalini Dyagala, Sairathna Choppella, Mahesh Kumar Ravva, Subit Kumar Saha   +4 more
wiley   +1 more source