Results 101 to 110 of about 42,058 (219)

Estrogen Receptor Beta Activation Coordinates Liver Lipid Remodeling and Metabolic Fluxes, Preventing Lipotoxicity

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
ERβ activation restores glucose and lipid homeostasis by remodeling the hepatic lipidome. Mechanistically, it promotes complete fatty acid oxidation and decreases Acetyl‐CoA levels, leading to reduced ketogenesis and lipotoxicity, as demonstrated through in vivo and in vitro approaches.
Debora Santos Rocha, Eloisa Vilas‐Boas, Camille C. Caldeira da Silva, Everton L. Vogt, Marcos Yoshinaga, Mariana Pacheco Teixeira de Carvalho, Maiara I. C. Queiroz, Tiago Eugênio Oliveira da Silva, Sayuri Miyamoto, Alicia J. Kowaltowski   +9 more
wiley   +1 more source

Polarized effects of adenosine on blood–brain barrier integrity: Tightening from the luminal and opening from the abluminal side

British Journal of Pharmacology, Volume 183, Issue 16, Page 4761-4777, August 2026.
Background and Purpose Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach The expression of adenosine receptors was measured by qRT‐PCR.
András Harazin, Gabriela Hurtado‐Alvarado, Lilla Barna, Arturo Contis‐Montes de Oca, Rocío Ruíz‐Manzano, Krisztián Laczi, András Kincses, Gergő Porkoláb, Gang Chen, Beatriz Gómez‐González, Mária A. Deli   +10 more
wiley   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Incorporation of Selenium into Sol–Gel‐Derived Bioactive Glass: Influence on Glass Structure, Bioactivity, and its Selective Cytotoxicity

Advanced Engineering Materials, Volume 28, Issue 14, 22 July 2026.
Selenium was incorporated into a sol–gel‐derived bioactive glass to enable sustained therapeutic ion release. The selenium‐containing glass preserved bioactivity while selectively inducing cytotoxicity in osteosarcoma cells and maintaining osteoblastic viability.
Breno Rocha Barrioni, Thalita Marcolan Valverde, Talita Martins, Guilherme Mattos Jardim Costa, Alfredo Miranda de Goes, Marcello Rosa Dumont, Eduardo Henrique Martins Nunes, Marivalda de Magalhães Pereira   +7 more
wiley   +1 more source

Sodium Selenite Inhibits Gamma-Secretase Activity through Activation of Erk [PDF]

, 2011
Previous studies have demonstrated that the ERK MAPK acts as a negative regulator of gamma-secretase. Here, we demonstrate that the activation of ERK MAPK pathway by sodium selenite can inhibit endogenous gamma-secretase activity. Consistently, the gamma-
董盈岑;許文明;王柏堅;嚴震東;胡明寬;廖永豐, TUNG, YING-TSEN;HSU, WEN-MING;WANG, BO-JENG;YEN, CHEN-TUNG;HU, MING-KUAN;LIAO, YUNG-FENG   +1 more
core  

Exploring the lipids, carotenoids, and vitamins content of Rhodotorula glutinis with selenium supplementation under lipid accumulating and growth proliferation conditions

BMC Microbiology
Background Rhodotorula glutinis, a specific type of yeast, has been recognised as a superior resource for generating selenium-enriched biomass that possesses exceptional nutritional and functional attributes.
Nora Elfeky, Aya Rizk, Mohamed M. Gharieb   +2 more
doaj   +1 more source

Lead nitrate induced nephrotoxicity and protective effect of sodium selenite in diabetic and non-diabetic rats [PDF]

, 2014
Kursun, yıllardır insanlara ve hayvanlara yüksek derecede toksik bir metal olarak tanımlanmıstır. Bu çalısmanın amacı kursun nitrat'ın diyabetik ve diyabetik olmayan ratların böbrek dokusu üzerine etkisini ve antioksidan özellige sahip oldugu bilinen ...
Baş, Hatice
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The effects of sodium selenite on serum lipid profile and atherogenic indexes in diabetic rats [PDF]

, 2015
Background: The prevalence of diabetes is rising in the world. The aim of this study was to determine the possible protective effect of sodium selenite on serum lipid profile and atherogenic indexes in Alloxan-induced Type 1 diabetic rats.
Maryam Hormozi, Gholamreza Shahsavari, Ali Khosrowbeygi, Foad Abdolahpour, Shahrokh Bagheri, Hasan Ahmadvand   +5 more
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ACUTE TOXICITY of SODIUM SELENITE and SODIUM SELENATE TO TILAPIA, Oreochromis niloticus, FINGERLINGS [PDF]

, 2011
Selenium is an essential nutrient for many organisms, including fish. It can be released in the water by natural processes of dissolving rocks and minerals, and by the wastewater from industries and agricultural activities, which can increase its ...
Goncalves, Adriano, Ranzani-Paiva, Maria Jose T., Lombardi, Julio Vicente   +2 more
core  

Extractive Electrospray Ionization Mass Spectrometry for Rapid Analysis of Organic and Inorganic Selenium in Honey

Molecules
Selenium, a crucial trace element for human health, plays a vital role in maintaining well-being. Its insufficiency can cause various diseases, highlighting the need for adequate selenium intake in daily diets.
Xinrui Zhang, Yuqi Qiu, Huiyu Xing, Feixiang Yang, Peng Zeng, Hao Fan, Huanwen Chen, Xiaowei Fang   +7 more
doaj   +1 more source