Results 91 to 100 of about 4,519 (191)

Pathology, multimodal imaging and clinical significance of age-related fundus deposits

Yanke Xuebao
Fundus aging is a key factor and pathological basis for the development and progression of age-related macular degeneration (AMD), which is histopathologically characterized by choroidal capillary atrophy, Bruch’s membrane(BrM) thickening, and ...
CAI Jinyu, JIANG Yanmei, CHEN Ling
doaj   +1 more source

Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration [PDF]

, 2015
International audiencePhysiologically, the retinal pigment epithelium (RPE) expresses immunosuppressive signals such as FAS ligand (FASL), which prevents the accumulation of leukocytes in the subretinal space.
Alexis‐Pierre Bemelmans, Ayroldi E, Basu SK, Bertrand Calippe, Christophe Combadiere, Elisa Dominguez, Florian Sennlaub, José‐Alain Sahel, Michael Housset, Michel Paques, Molday RS, Oh H, Olivier Levy, Ong JM, Shulong J Hu, Sophie Lavalette, Um HD, Wenkel H, William Raoul, Xavier Guillonneau   +19 more
core   +3 more sources

Fluorescence lifetime and peak emission wavelength differ between AMD patients with soft drusen and sub-retinal drusenoid deposits. [PDF]

Acta Ophthalmol, 2022
Simon R, Curcio CA, Weber S, Meller D, Hammer M.   +4 more
europepmc   +1 more source

Blood pressure, atherosclerosis, and the incidence of age-related maculopathy: the Rotterdam Study [PDF]

, 2003
PURPOSE: To determine whether blood pressure and subclinical atherosclerosis are associated with incident age-related maculopathy (ARM). METHODS: The study was performed within the Rotterdam Study, a population-based, prospective cohort
Hofman, A. (Albert), Ikram, M.K. (Kamran), Jong, P.T.V.M. (Paulus) de, Leeuwen, R. (Redmer) van, Vingerling, J.R. (Hans), Witteman, J.C.M. (Jacqueline)   +5 more
core  

Soft drusen accumulation within a full-thickness macular hole: new insights into the mechanisms of lipid cycling pathways in age-related macular degeneration. [PDF]

Eye (Lond), 2022
Ramtohul P, Cabral D, Klancnik JM, Curcio CA, Freund KB.   +4 more
europepmc   +1 more source

Somatostatin receptor 2A expression in choroidal neovascularization secondary to age-related macular degeneration [PDF]

, 2000
PURPOSE: The growth of ocular neovascularization is regulated by a balance between stimulating and inhibiting growth factors. Somatostatin affects angiogenesis by inhibiting the growth hormone-insulin-like growth factor axis
Baarsma, G.S. (Seerp), Hagen, P.M. (Martin) van, Kliffen, M. (Mike), Kuijpers, R.W.A.M. (Robert), Lambooij, A.C. (Antoinette), Lichtenauer-Kaligis, E.G. van, Mooy, C.M. (Cornelia)   +6 more
core  

Topographic Distribution and Progression of Soft Drusen Volume in Age-Related Macular Degeneration Implicate Neurobiology of Fovea. [PDF]

Invest Ophthalmol Vis Sci, 2021
Pollreisz A, Reiter GS, Bogunovic H, Baumann L, Jakob A, Schlanitz FG, Sacu S, Owsley C, Sloan KR, Curcio CA, Schmidt-Erfurth U.   +10 more
europepmc   +1 more source

Age-Related Macular Degeneration in the Aspect of Chronic Low-Grade Inflammation (Pathophysiological ParaInflammation)

Mediators of Inflammation, 2014
The products of oxidative stress trigger chronic low-grade inflammation (pathophysiological parainflammation) process in AMD patients. In early AMD, soft drusen contain many mediators of chronic low-grade inflammation such as C-reactive protein, adducts ...
Małgorzata Nita, Andrzej Grzybowski, Francisco J. Ascaso, Valentín Huerva   +3 more
doaj   +1 more source

Long-term effect of prophylactic laser treatment for bilateral soft drusen.

Chinese medical journal, 2011
Large drusen is a known risk factor for the development of late complications of age-related macular degeneration (AMD) and drusen reduction has been found by our previous study. To prospectively evaluate the efficacy and safety of prophylactic laser treatment in Chinese patients with bilateral soft drusen, we examined the structure and function of the
Ying-xiang, Huang, Li-nan, Xiang, Yan-ling, Wang, Ming-min, Li, Yong-xia, Hu   +4 more
openaire   +1 more source

Age-related changes in the macula. A histopathological study of fifty Indian donor eyes

Indian Journal of Ophthalmology, 2002
PURPOSE: Age-related macular degeneration (ARMD) is clinically less common in India compared to the West. Therefore, clinicians are unfamiliar with histopathologic evidence of age-related macular changes in the Indian population.
Biswas Jyotirmay, Raman Rajiv
doaj