Results 31 to 40 of about 2,316 (217)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

An adaptive soft sensor deterioration evaluation and model updating method for time-varying chemical processes [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2020
Due to the time-varying nature of chemical processes, soft sensor models deteriorate, and data prediction accuracy decreases. To address this problem, an adaptive soft sensor modeling method is proposed that not only evaluates the model deterioration by ...
Li Longhao, Dai Yongshou
doaj   +1 more source

A Soft Sensor for Bleeding Detection in Colonoscopies

Advanced Intelligent Systems, 2022
Colonoscopies allow surgeons to detect common diseases, that is, colorectal cancer, ulcers, and other ailments. However, there is a risk of bleeding in the lower gastrointestinal (GI) tract while maneuvering endoscopes. This may be due to perforations, hemorrhaging, polyps, diverticula, or post‐biopsy complications.
Arincheyan Gerald, Max McCandless, Avani Sheth, Hiroyuki Aihara, Sheila Russo   +4 more
openaire   +4 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Low-cost, data-efficient, on-device soft sensors for sewer flow monitoring—learning from adjacent water level sensors

Water Research X
Flow measurements are critical for sewer monitoring, but direct measurements with flow meters are often expensive due to high sensor costs and frequent sensor maintenance.
Ruozhou Lin, Wenchong Tian, Ruihong Qiu, Lihan Hu, Zhiguo Yuan   +4 more
doaj   +1 more source

Development of a Multi-Model Strategy Based Soft Sensor Using Gaussian Process Regression and Principal Component Analysis in Fermentation Processes

Chemical Engineering Transactions, 2017
In fermentation processes, single model based soft sensors cannot guarantee prediction performance owing to process characteristics of non-linearity, shifting operating modes, dynamics and uncertainty.
C. Mei, Y. Chen, H. Zhang, X. Chen, G. Liu   +4 more
doaj   +1 more source

Triboelectric nanogenerator sensors for soft robotics aiming at digital twin applications

Nature Communications, 2020
Designing efficient sensors for human machine interaction remains a challenge. Here, the authors present a soft robotic fingers system based on a triboelectric nanogenerator (L-TENG) sensor to capture the continuous motion of soft gripper and a soft ...
Tao Jin, Zhongda Sun, Long Li, Quan Zhang, Minglu Zhu, Zixuan Zhang, Guangjie Yuan, Tao Chen, Yingzhong Tian, Xuyan Hou, Chengkuo Lee   +10 more
doaj   +1 more source