Results 41 to 50 of about 5,890,786 (352)

Efficacy and safety of sintilimab plus doxorubicin in advanced soft tissue sarcoma: A single-arm, phase II trial

Frontiers in Pharmacology, 2022
Background: Chemoimmunotherapy is safe and efficacious in treating many types of malignant tumors. However, clinical data demonstrating the effect of this combination treatment in patients with metastatic soft tissue sarcoma (STS) are currently limited ...
Zhichao Tian, Shuping Dong, Wenli Zuo, Po Li, Fan Zhang, Shilei Gao, Yonghao Yang, Chao Li, Peng Zhang, Xin Wang, Jiaqiang Wang, Weitao Yao   +11 more
doaj   +1 more source

LncRNA PCBP1-AS1-mediated AR/AR-V7 deubiquitination enhances prostate cancer enzalutamide resistance

Cell Death and Disease, 2021
The refractory of castration-resistant prostate cancer (CRPC) is mainly reflected in drug resistance. The current research on the resistance mechanism of CRPC is still in its infancy.
Boya Zhang, Mingpeng Zhang, Chunyi Shen, Guancong Liu, Fan Zhang, Jingyu Hou, Weitao Yao   +6 more
doaj   +1 more source

Soft-tissue specimens from pre-European extinct birds of New Zealand [PDF]

, 2012
We provide the first complete review of soft tissue remains from New Zealand birds that became extinct prior to European settlement (c. AD 1800). These rare specimens allow insights into the anatomy and appearance of the birds that are not attainable ...
Fraser, C, Rawlence, Nicolas J., Scofield, R. P., Tennyson, A. J. D., Wood, Jamie R.   +4 more
core   +2 more sources

Nanofiber-hydrogel composite–mediated angiogenesis for soft tissue reconstruction

Science Translational Medicine, 2019
A biodegradable nanofiber-hydrogel composite material promotes angiogenesis for soft tissue reconstruction in rodent and rabbit models. Crafting a (re)constructive composite To be useful for soft tissue reconstruction, a biomaterial should be compatible ...
Xiaowei Li, Brian Cho, Russell Martin, Michelle Y. Seu, Chi Zhang, Zhengbing Zhou, J. Choi, Xuesong Jiang, Long Chen, Gurjot Walia, Jerry Yan, Megan Callanan, Huanhuan Liu, K. Colbert, Justin Morrissette-McAlmon, W. Grayson, Sashank K Reddy, J. Sacks, H. Mao   +18 more
semanticscholar   +1 more source

Single-cell multi-omics elucidates the role of RPS27-RPS24 fusion gene in osteosarcoma chemoresistance and metabolic regulation

Cell Death Discovery
Osteosarcoma (OS) presents significant treatment challenges due to chemoresistance. This study explores the molecular mechanisms underlying chemoresistance in OS, focusing on the novel fusion gene RPS27-RPS24. Using single-cell multi-omics techniques, we
Zhiwei Tao, Pingan Zou, Zhengxu Yang, Tao Xiong, Zhi Deng, Qincan Chen   +5 more
doaj   +1 more source

Extracellular matrix-based scaffolding technologies for periodontal and peri-implant soft tissue regeneration.

The Journal of Periodontology, 2019
The present article focuses on the properties and indications of scaffold-based extracellular matrix technologies as alternatives to autogenous soft tissue grafts for periodontal and peri-implant plastic surgical reconstruction.
L. Tavelli, M. McGuire, G. Zucchelli, G. Rasperini, S. Feinberg, Hom-lay Wang, W. Giannobile   +6 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

LncRNAs regulates cell death in osteosarcoma

Scientific Reports
Despite improvements, prognosis in osteosarcoma patients remains poor, making it essential to identify additional and more robust therapeutic targets. Non-apoptotic receptor-mediated cell death (RCD), which plays a crucial role in the pathogenesis of OS,
Ping’an Zou, Zhiwei Tao, Zhengxu Yang, Tao Xiong, Zhi Deng, Qincan Chen, Li Niu   +6 more
doaj   +1 more source

PNO1 promotes the progression of osteosarcoma via TGF-β and YAP/TAZ pathway

Scientific Reports, 2023
This study aimed to explore the potential role and mechanisms of the partner of NOB1 homolog (PNO1) in osteosarcoma. The expression of PNO1 in tumor and adjacent tissue samples was examined using western blotting.
Long Fang, Baolong Wang, Zengkun Yang, Tingbao Zhao, Wei Hao   +4 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source