Results 41 to 50 of about 5,235,793 (361)

Lymph node metastasis in extremity chondrosarcomas

South Asian Journal of Cancer, 2020
Bacground: Primary bone sarcomas mainly metastasize through haematogenous route and rarely through lymph nodes due to paucity of lymphatic channels in the bone (1).
Vineet Kurisunkal, Ashish Gulia, Puri Ajay, Bharat Rekhi   +3 more
doaj   +1 more source

PNO1 promotes the progression of osteosarcoma via TGF-β and YAP/TAZ pathway

Scientific Reports, 2023
This study aimed to explore the potential role and mechanisms of the partner of NOB1 homolog (PNO1) in osteosarcoma. The expression of PNO1 in tumor and adjacent tissue samples was examined using western blotting.
Long Fang, Baolong Wang, Zengkun Yang, Tingbao Zhao, Wei Hao   +4 more
doaj   +1 more source

Layer-by-layer ultraviolet assisted extrusion-based (UAE) bioprinting of hydrogel constructs with high aspect ratio for soft tissue engineering applications

PLoS ONE, 2019
One of the major challenges in the field of soft tissue engineering using bioprinting is fabricating complex tissue constructs with desired structure integrity and mechanical property.
Pei Zhuang, Wei Long Ng, J. An, C. Chua, L. P. Tan   +4 more
semanticscholar   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

The fusion gene LRP1–SNRNP25 drives invasion and migration by activating the pJNK/37LRP/MMP2 signaling pathway in osteosarcoma

Cell Death Discovery
Through transcriptome sequencing, we previously identified a new osteosarcoma-specific, frequent fusion gene, LRP1–SNRNP25, and found that it played an important role in tumor cell invasion and migration.
Peipei Xing, Haotian Liu, Wanyi Xiao, Gengpu Zhang, Chao Zhang, Zhichao Liao, Ting Li, Jilong Yang   +7 more
doaj   +1 more source

Phase II trial of VEGFR2 inhibitor apatinib for metastatic sarcoma: focus on efficacy and safety

Experimental and Molecular Medicine, 2019
Cancer: Starving sarcomas into submission A drug that inhibits blood vessel growth offers a potentially promising treatment for a class of tumors with a poor prognosis.
Zhichao Liao, Feng Li, Chao Zhang, Lei Zhu, Yehui Shi, Gang Zhao, Xu Bai, Shafat Hassan, Xinyue Liu, Ting Li, Peipei Xing, Jun Zhao, Jin Zhang, Ruwei Xing, Sheng Teng, Yun Yang, Kexin Chen, Jilong Yang   +17 more
doaj   +1 more source

Comparison of seventh and eighth edition of AJCC staging system in melanomas at locoregional stage

World Journal of Surgical Oncology, 2019
Background The eighth edition of the American Joint Committee on Cancer (AJCC) staging system has been effective since January 2018. It has introduced some major changes in the localized/locoregional melanoma classification.
Pawel Teterycz, Iwona Ługowska, Hanna Koseła-Paterczyk, Piotr Rutkowski   +3 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Identification and characterization of mitochondrial autophagy-related genes in osteosarcoma and predicting clinical prognosis

Scientific Reports
Osteosarcoma (OS), the most prevalent primary malignant bone tumor, is characterized by a poor prognosis and high metastatic potential. Mitochondrial autophagy has been implicated in cancer suppression.
Hongliang Zhang, Jingyu Zhang, Kai Zhu, Shuang Li, Jinwei Liu, Boya Guan, Hong Zhang, Changbao Chen, Yancheng Liu   +8 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source