Results 61 to 70 of about 1,408,519 (358)

Soft tissue sarcoma

BMJ, 2016
#### What you need to know A 45 year old woman presented to her general practitioner several times over nine months with a gradually enlarging, hard lump in her anterior thigh. An ultrasound scan showed a solid intramuscular mass in the anterior compartment of her thigh, prompting a two week wait referral to the regional sarcoma diagnostic clinic ...
Eastley, Nicholas Charles, Green, P. N., Ashford, R. U.   +2 more
openaire   +3 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Upregulation of long non-coding RNA SNHG11 promotes apoptosis and its molecular mechanisms in human osteosarcoma U2OS cells

Scientific Reports
Osteosarcoma (OS) is a malignant bone tumor of mesenchymal origin, which is common in children and adolescents. Long non-coding RNA (lncRNA) SNHG11 plays important regulatory roles in various cancers, particularly in promoting cell migration, invasion ...
Zhibing Dai, Yachao Sun, Maierdanjiang Maihemuti, JunWei Du, Renbing Jiang   +4 more
doaj   +1 more source

BRAF mutation and its inhibitors in sarcoma treatment

Cancer Medicine, 2020
The mitogen‐activated protein kinase (MAPK) signaling pathway plays a significant role in mediating cellular physiological activities, such as proliferation, differentiation, apoptosis, and senescence.
Haotian Liu, Nahar Nazmun, Shafat Hassan, Xinyue Liu, Jilong Yang   +4 more
doaj   +1 more source

Environmental stiffness restores mechanical homeostasis in vimentin-depleted cells

Scientific Reports, 2023
Recent experimental evidence indicates a role for the intermediate filament vimentin in regulating cellular mechanical homeostasis, but its precise contribution remains to be discovered. Mechanical homeostasis requires a balanced bi-directional interplay
Janine Grolleman, Nicole C. A. van Engeland, Minahil Raza, Sepinoud Azimi, Vito Conte, Cecilia M. Sahlgren, Carlijn V. C. Bouten   +6 more
doaj   +1 more source

Soft Tissue to Hard Tissue Advancement Ratios for Mandibular Elongation Using Distraction Osteogenesis in Children [PDF]

, 2006
Distraction osteogenesis is extensively used for the elongation of hypoplastic mandibles in children, yet the soft tissue profile response to this is not well understood.
Bergstrom, Christopher A., Bradley, T. Gerard, Hanson, Pamela R., Melugin, Michael B., Schuckit, William I.   +4 more
core   +1 more source

Polyhexamethylene Biguanide and Nadifloxacin Self-Assembled Nanoparticles: Antimicrobial Effects against Intracellular Methicillin-Resistant Staphylococcus aureus [PDF]

, 2018
The treatment of skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA) remains a challenge, partly due to localization of the bacteria inside the host’s cells, where antimicrobial penetration and efficacy is limited.
Chivu, A, de Fatima Pina, M, Good, L, Kamaruzzaman, N F   +3 more
core   +3 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

MTHFD1L is a novel prognostic marker and therapeutic target in cutaneous melanoma

Diagnostic Pathology
Background Skin cutaneous melanoma (SKCM) is one of the highly malignant tumor. This study aimed to investigate the expression levels of MTHFD1L in cutaneous melanoma and to uncover its potential biological significance.
Xinlian Xie, Guangfu Shi, Kebin Ning, Zhenjie Wu   +3 more
doaj   +1 more source

Inhibition of spontaneous and experimental lung metastasis of soft-tissue sarcoma by tumor-targeting Salmonella typhimurium A1-R. [PDF]

, 2014
Prognosis of patients with lung metastases of soft-tissue sarcoma is still poor. Therefore, novel systemic therapy is needed to improve the survival of soft-tissue sarcoma.
Baek, Kyung-Eun, Bouvet, Michael, Hayashi, Katsuhiro, Hiroshima, Yukihiko, Hoffman, Robert M, Kimura, Hiroaki, Matsumoto, Yasunori, Miwa, Shinji, Tsuchiya, Hiroyuki, Uehara, Fuminari, Yamamoto, Mako, Yamamoto, Norio, Yano, Shuya, Zhang, Yong, Zhao, Ming   +14 more
core   +3 more sources