Results 61 to 70 of about 173,430 (355)

Systemic inflammation index is a predictive and prognostic factor in patients with liposarcoma or leiomyosarcoma treated with trabectedin

Scientific Reports
Trabectedin is a chemotherapeutic agent that has shown activity in the treatment of patients with soft tissue sarcomas after failure of anthracycline-based therapy and the best results were recorded in the treatment of L-sarcomas.
Pawel Sobczuk, Paulina Filipowicz, Lukasz Lamparski, Hanna Kosela-Paterczyk, Pawel Teterycz, Katarzyna Kozak, Paweł Rogala, Tomasz Świtaj, Sławomir Falkowski, Piotr Rutkowski   +9 more
doaj   +1 more source

Lymphadenectomy in the treatment of sarcomas – indications and technique

Oncology Reviews
Sarcomas are a rare type of malignancy with limited treatment options so far. This analysis aimed to describe the impact of lymphadenectomy on treating sarcoma patients. Sarcomas characterized by lymphatic spread are rare.
Piotr Dunaj, Piotr Dunaj, Ewa Żukowska, Ewa Żukowska, Anna M. Czarnecka, Maria Krotewicz, Aneta Borkowska, Paulina Chmiel, Paulina Chmiel, Tomasz Świtaj, Piotr Rutkowski   +10 more
doaj   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Efficacy of radiotherapy and radiotherapy with hyperthermia to delay change of systemic therapy in patients with metastatic melanoma

Clinical and Translational Radiation Oncology
Background: The use of radiotherapy (RT) and RT with hyperthermia (HT) as a local treatment for oligoprogression in many tumors is becoming increasingly prevalent.
Paulina Chmiel, Mateusz Jacek Spałek, Hanna Koseła-Paterczyk, Piotr Łukasz Rutkowski, Paulina Jagodzińska-Mucha, Paweł Rogala, Katarzyna Kozak, Maria Telejko, Aneta Maria Borkowska   +8 more
doaj   +1 more source

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma. [PDF]

, 2016
BackgroundLeiomyosarcoma (LMS) is a common type of soft tissue sarcoma that responds poorly to standard chemotherapy. Thus the goal of this study was to identify novel selective therapies that may be effective in leiomyosarcoma by screening cell lines ...
Al-Awar, Rima, Babichev, Yael, Boutros, Paul C, Datti, Alessandro, Dickson, Brendan C, Gladdy, Rebecca A, Isaac, Methvin, Kabaroff, Leah, Prakesch, Michael, Sun, Ren X, Uehling, David, Venier, Rosemarie   +11 more
core   +2 more sources

Endothelial Cells Angiogenesis in Sulfated Glycosaminoglycan (GAG) Hydrogels Enhanced by Bioactive Glass‐Released Ions

Advanced Functional Materials, EarlyView.
A mechanically tunable hydrogel composed of gelatin, chondroitin sulfate and laminin promotes angiogenesis in vitro without the supplement of growth factors. Endothelial cells morphogenesis was further enhanced by medium conditioned with bioactive glass 58S‐released ions (Ca and Si), thus offering a promising strategy to vascularize 3D tissue ...
Marco Piazzoni, Ilaria Borghi, Francesca Cadamuro, Sophia Dalfino, Riccardo Campanile, Sofia Nizzolo, Valeria Cassina, Francesca Tallia, Julian R. Jones, Francesco Mantegazza, Sabrina Bertini, Lorenzo Moroni, Francesco Nicotra, Laura Russo   +13 more
wiley   +1 more source

From pathogenesis to the patient’s bedside: a comprehensive review of extraskeletal myxoid chondrosarcoma

Journal of Cancer Research and Clinical Oncology
Extraskeletal myxoid chondrosarcoma (EMC) is characterised by recurrent NR4A3 gene rearrangements, most commonly EWSR1::NR4A3, and accounts for approximately 1–3% of soft-tissue sarcomas (STS). It typically arises in the deep soft tissues of the proximal
Piotr Remiszewski, Sławomir Falkowski, Anna Szumera-Ciećkiewicz, Mateusz J. Spałek, Piotr Rutkowski, Anna M. Czarnecka   +5 more
doaj   +1 more source

Molecular and Clinicopathological Biomarkers in the Neoadjuvant Treatment of Patients with Advanced Resectable Melanoma

Biomedicines
Neoadjuvant systemic therapy is emerging as the best medical practice in patients with resectable stage III melanoma. As different regimens are expected to become available in this approach, the improved optimization of treatment strategies is required ...
Piotr J. Błoński, Anna M. Czarnecka, Krzysztof Ostaszewski, Anna Szumera-Ciećkiewicz, Piotr Rutkowski   +4 more
doaj   +1 more source

The significance of margins in pediatric Non‐Rhabdomyosarcoma soft tissue sarcomas: Consensus on surgical margin definition harmonization from the INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT)

Cancer Medicine, 2023
Background Margin status following surgery in children, adolescents, and young adults with soft tissue sarcomas is controversial and has been defined differently by various specialties, with definitions changing over time and by cooperative group.
Monika Sparber‐Sauer, Andrea Ferrari, Sheri L. Spunt, Christian Vokuhl, Dana Casey, Timothy B. Lautz, William H. Meyer, David O. Walterhouse, Kristian W. Pajtler, Rita Alaggio, Andreas Schmidt, Akmal Safwat, Beate Timmermann, Patrizia Dall'Igna, Sonja Chen, Aaron R. Weiss, Daniel Orbach   +16 more
doaj   +1 more source

Rare case of clear cell sarcoma in a young female [PDF]

, 2010
Clear Cell Sarcoma of Tendon and Aponeuroses (CCTA), also known as Melanoma of soft tissue is a rare and highly malignant soft tissue neoplasm which mostly occurs in young adults A 26-year-old female presented with pain and thickened soft tissue in the ...
Bahador, Farshad Michael, Egner, James, Khaliq, Waseem, Musselman, Mark S., Uzoaru, Ikechukwu   +4 more
core