Results 51 to 60 of about 2,534,544 (260)

Outcomes of systemic treatment in advanced melanoma after progression on anti–PD-1 therapy: a real-world study with literature review

Oncology in Clinical Practice
INTRODUCTION: Currently, a substantial proportion of patients are still treated with first-line anti-PD-1 immunotherapy (ICI). After disease progression, treatment options, especially for patients with BRAF-negative tumors, are limited.
Piotr J. Błoński, Krzysztof Ostaszewski, Barbara Buchalska, Julia Szymkiewicz, Tomasz Switaj, Paweł Rogala, Katarzyna Kozak, Monika Dudzisz-Śledź, Anna M. Czarnecka   +8 more
doaj   +1 more source

Modern Dressings in Prevention and Therapy of Acute and Chronic Radiation Dermatitis—A Literature Review

Pharmaceutics, 2022
Radiotherapy is an integral part of modern oncology, applied to more than half of all patients diagnosed with cancer. It can be used alone or in combination with surgery or chemotherapy.
Konrad Zasadziński, Mateusz Jacek Spałek, Piotr Rutkowski   +2 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Proton beam therapy in paediatric cancer: Anticipating the opening of the Australian Bragg Centre for Proton Therapy and Research

Journal of Medical Imaging and Radiation Oncology, EarlyView., 2023
Summary Proton Beam Therapy (PBT) has the potential to improve paediatric cancer care by reducing radiation exposure and thus long‐term toxicities. Ethical concerns and debates surrounding the treatment, such as eligibility and accessibility, are ongoing in Australia. The Australian Bragg Centre for Proton Therapy and Research (ABCPTR) (named after Sir
Jeremy Khong, Hui Tee, Peter Gorayski, Hien Le, Michael Penniment, Sophie Jessop, Jordan Hansford, Melanie Penfold, Julia Green, Kelly Skelton, Frank Saran   +10 more
wiley   +1 more source

Systemic inflammation index is a predictive and prognostic factor in patients with liposarcoma or leiomyosarcoma treated with trabectedin

Scientific Reports
Trabectedin is a chemotherapeutic agent that has shown activity in the treatment of patients with soft tissue sarcomas after failure of anthracycline-based therapy and the best results were recorded in the treatment of L-sarcomas.
Pawel Sobczuk, Paulina Filipowicz, Lukasz Lamparski, Hanna Kosela-Paterczyk, Pawel Teterycz, Katarzyna Kozak, Paweł Rogala, Tomasz Świtaj, Sławomir Falkowski, Piotr Rutkowski   +9 more
doaj   +1 more source

Cardiac tumor as first presentation of melanoma

Oncology in Clinical Practice
Melanoma metastases most commonly involve the skin, lungs, central nervous system, and liver. In 1.8% of all patients with melanoma, cardiac metastases are diagnosed.
Magdalena K. Zielińska, Monika Dudzisz-Śledź, Krzysztof Ostaszewski, Aneta Borkowska, Anna M. Czarnecka   +4 more
doaj   +1 more source

Mucoepidermoid carcinoma mimicking a soft tissue sarcoma: a case report [PDF]

, 2007
We describe a case that initially presented to the oncology unit as what seemed like a soft tissue sarcoma arising from the thigh. Biopsy of this mass showed that it was a mucoepidermoid carcinoma. This is a very rare presentation of a non-salivary gland
Sandhu, S.S., George, J., Singh, V.A.
core  

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma

, 2018
Carbon ion radiotherapy is known for its high‐precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution.
Tadashi Kamada, Reiko Imai, Nobuhito Araki, and the Working Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas   +3 more
core   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source