Results 31 to 40 of about 2,533,606 (305)

Targeting TIMM23 to overcome osteosarcoma chemoresistance

Cell Death and Disease
Osteosarcoma (OS) is a malignant tumor whose chemoresistance severely compromises therapeutic efficacy. This study aims to investigate the molecular mechanism by which TIMM23 mediates M2 polarization of macrophages through mitophagy and regulates TIMM23 ...
Zhiwei Tao, Pingan Zou, Zhengxu Yang, Tao Xiong, Zhi Deng, Qinchan Chen   +5 more
doaj   +1 more source

Tebentafusp (IMCgp100) in the treatment of uveal melanoma — from preclinical evidence to clinical practice

Nowotwory
Tebentafusp (IMCgp100) is a novel bispecific immunotherapy that contains a specifically engineered soluble T-cellreceptor (TCR) capable of recognising the gp100 epitope on the surface of tumour cells presented by human leukocyteantigen-A*02:01 (HLA- A*02:
Piotr Remiszewski, Eryk Siedlecki, Julia Wąż, Kinga Filipek, Agata Pisklak, Wiktor Gaik, Monika Dudzisz-Śledź, Piotr Rutkowski, Anna M. Czarnecka   +8 more
doaj   +1 more source

The Effect of Photodynamic Therapy Using 5-Aminolevulinic Acid in Bone and Soft Tissue Sarcoma Cells [PDF]

三重大学博士(医学)application/pdfBackground/Aim: 5-Aminolevulinic acid(5-ALA) is a natural amino acid and a precursor of protoporphyrin IX (PpIX). Following light irradiation, the PpIX generates reactive oxygen species (ROS) in the presence of oxygen.
アダチ, リョウヘイ, 足立, 量平, ADACHI, RYOHEI   +2 more
core   +1 more source

A Situational Assessment of the Diagnostic Landscape and Organizational Readiness to Implement Next‐Generation Sequencing at Two Childhood Cancer Treatment Centers in Ghana

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho, Emmanuella Amoako, Nihad Salifu, Lily Gloria Tagoe, Yaw Bediako, Michelle Hermiston, Catherine Segbefia   +6 more
wiley   +1 more source

Single-cell multi-omics elucidates the role of RPS27-RPS24 fusion gene in osteosarcoma chemoresistance and metabolic regulation

Cell Death Discovery
Osteosarcoma (OS) presents significant treatment challenges due to chemoresistance. This study explores the molecular mechanisms underlying chemoresistance in OS, focusing on the novel fusion gene RPS27-RPS24. Using single-cell multi-omics techniques, we
Zhiwei Tao, Pingan Zou, Zhengxu Yang, Tao Xiong, Zhi Deng, Qincan Chen   +5 more
doaj   +1 more source

Malignant melanoma with cardiac involvement: a case report and literature review

Oncology in Clinical Practice
INTRODUCTION: Malignant melanoma is the tumor most frequently associated with cardiac metastases. Melanocytes originate from the neural crest, which may underlie the tumor’s propensity for widespread hematogenous dissemi-nation, including to the heart ...
Aleksander Gorzeń, Tomasz Świtaj, Paweł Rogala, Hanna Koseła-Paterczyk, Karolina Sosnowska, Paweł Teterycz, Katarzyna Kozak, Piotr Rutkowski, Anna M. Czarnecka   +8 more
doaj   +1 more source

Zalecenia Polskiej Grupy Mięsakowej odnośnie postępowania diagnostyczno-terapeutycznego oraz kontroli u chorych na neurofibromatozę typu 1 (NF1) oraz malignant peripheral nerve sheath tumor związany z NF1

Nowotwory, 2022
Neurofibromatoza typu 1 (zespół NF1 in. choroba Recklinghausena, nerwiakowłókniakowatość typu 1), jest dziedziczona autosomalnie dominująco, a odpowiadają za nią mutacje genu NF1 kodującego białko neurofibrominy.
Piotr Rutkowski, Anna Raciborska, Anna Szumera-Ciećkiewicz, Paweł Sobczuk, Mateusz Spałek, Hanna Koseła-Paterczyk, Iwona Ługowska, Katarzyna Bilska, Monika Gos, Janusz Ryś, Ewa Chmielik, Andrzej Tysarowski, Konrad Zaborowski, Małgorzata Oczko-Wojciechowska, Patrycja Castaneda-Wysocka, Donata Makuła, Marcin Zdzienicki, Marcin Ziętek, Piotr Fonrobert, Kamil Dolecki, Marek Dedecjus, Anna M. Czarnecka   +21 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

LncRNAs regulates cell death in osteosarcoma

Scientific Reports
Despite improvements, prognosis in osteosarcoma patients remains poor, making it essential to identify additional and more robust therapeutic targets. Non-apoptotic receptor-mediated cell death (RCD), which plays a crucial role in the pathogenesis of OS,
Ping’an Zou, Zhiwei Tao, Zhengxu Yang, Tao Xiong, Zhi Deng, Qincan Chen, Li Niu   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source