Results 61 to 70 of about 2,534,544 (260)

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Chemotherapy Strategies and Their Efficacy for Mesenchymal Chondrosarcoma

Current Oncology
Mesenchymal chondrosarcoma (MCS) is characterised by small round cell biology, frequent HEY1-NCOA2 fusion, and high vascularity. These features plausibly lessen extracellular matrix barriers and confer relative chemosensitivity.
Piotr Remiszewski, Julia Wąż, Sławomir Falkowski, Piotr Rutkowski, Anna M. Czarnecka   +4 more
doaj   +1 more source

Soft tissue tumors: Alveolar soft part sarcoma [PDF]

, 2008
Review on Soft tissue tumors: Alveolar soft part sarcoma, with data on clinics, and the genes ...
Huret, JL
core   +1 more source

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

Advanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei, Tanja Groll, Stephanie Kahl, Silke Baer, Elisabeth Bliemsrieder, Frits H. A. van Heijster, Andre Wendlinger, Pascal Wodtke, Jorge Cabello, Susan Notohamiprodjo, Christian Lohrmann, Markus Schwaiger, Wolfgang A. Weber, Katja Steiger, Andrea Meyer‐Lindenberg, Johannes Hirschberger, Christine Baumgartner, Franz Schilling   +17 more
wiley   +1 more source

Lymphadenectomy in the treatment of sarcomas – indications and technique

Oncology Reviews
Sarcomas are a rare type of malignancy with limited treatment options so far. This analysis aimed to describe the impact of lymphadenectomy on treating sarcoma patients. Sarcomas characterized by lymphatic spread are rare.
Piotr Dunaj, Piotr Dunaj, Ewa Żukowska, Ewa Żukowska, Anna M. Czarnecka, Maria Krotewicz, Aneta Borkowska, Paulina Chmiel, Paulina Chmiel, Tomasz Świtaj, Piotr Rutkowski   +10 more
doaj   +1 more source

Soft tissue tumors: Alveolar soft part sarcoma [PDF]

, 2001
Review on Soft tissue tumors: Alveolar soft part sarcoma, with data on clinics, and the genes ...
Huret, JL
core   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Efficacy of radiotherapy and radiotherapy with hyperthermia to delay change of systemic therapy in patients with metastatic melanoma

Clinical and Translational Radiation Oncology
Background: The use of radiotherapy (RT) and RT with hyperthermia (HT) as a local treatment for oligoprogression in many tumors is becoming increasingly prevalent.
Paulina Chmiel, Mateusz Jacek Spałek, Hanna Koseła-Paterczyk, Piotr Łukasz Rutkowski, Paulina Jagodzińska-Mucha, Paweł Rogala, Katarzyna Kozak, Maria Telejko, Aneta Maria Borkowska   +8 more
doaj   +1 more source

Concurrent Germline RB1 & Mosaic TP53 in a Child With Multiple Childhood Cancers

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We report a patient with a pathogenic germline variant (PGV) in RB1 and somatic mosaicism for a pathogenic TP53 variant who developed three distinct types of childhood cancer: retinoblastoma, osteosarcoma, and myelodysplastic syndrome (MDS) before the age of 6 years.
Ole Haubjerg Nielsen, Ulrik Kristoffer Stoltze, Pernille Axél Gregersen, Marianne Hoffmann, Morten Lyng Høgild, Mette Klarskov Andersen, Lise Barlebo Ahlborn, Lisa Lyngsie Hjalgrim, Karin A. W. Wadt   +8 more
wiley   +1 more source

From pathogenesis to the patient’s bedside: a comprehensive review of extraskeletal myxoid chondrosarcoma

Journal of Cancer Research and Clinical Oncology
Extraskeletal myxoid chondrosarcoma (EMC) is characterised by recurrent NR4A3 gene rearrangements, most commonly EWSR1::NR4A3, and accounts for approximately 1–3% of soft-tissue sarcomas (STS). It typically arises in the deep soft tissues of the proximal
Piotr Remiszewski, Sławomir Falkowski, Anna Szumera-Ciećkiewicz, Mateusz J. Spałek, Piotr Rutkowski, Anna M. Czarnecka   +5 more
doaj   +1 more source