Results 81 to 90 of about 150,928 (204)

Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma

Diagnostic Pathology, 2019
A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens.
Joanna Przybyl, Matt van de Rijn, Piotr Rutkowski   +2 more
doaj   +1 more source

Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma. [PDF]

, 2014
While liposarcoma is the second most common soft tissue malignant tumor, the molecular pathogenesis in this malignancy is poorly understood. Our goal was therefore to expand the understanding of molecular mechanisms that drive liposarcoma and identify ...
Borger, Darrell R, Choy, Edwin, Cote, Gregory, Duan, Zhenfeng, Fan, Kenneth C, Guo, Shang, Harmon, David, Hornicek, Francis J, Lopez-Marquez, Hector, Mankin, Henry, Nielsen, G Petur, Yang, Cao, Zhang, Changqing   +12 more
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A pattern of local failure after preoperative 5 × 5 Gy in soft tissue sarcomas: A long-term real-world experience

Clinical and Translational Radiation Oncology
Introduction: Preoperative radiotherapy (RT) is used to improve local control (LC) and facilitate limb-sparing procedures in patients with localized soft tissue sarcomas (STS).
Konrad Zasadziński, Aneta Borkowska, Tadeusz Morysiński, Hanna Koseła-Paterczyk, Piotr Rutkowski, Mateusz Jacek Spałek   +5 more
doaj   +1 more source

Effect of Surgical Excision Combined with Brachytherapy Treatment on Sarcoma Surrounding Important Nerve and Blood Vessels

Zhongliu Fangzhi Yanjiu, 2019
Objective To analyze the efficacy and safety of surgical excision combined with brachytherapy treatment on sarcoma surrounding important nerve and blood vessels.
ZHANG Chao, WANG Guowen, HAN Xiuxin, TENG Sheng, MA Yulin, CHEN Zhongjie, SUN Wujun   +6 more
doaj   +1 more source

Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas

Nature Communications
A major challenge hampering therapeutic advancements for high-risk sarcoma patients is the broad spectrum of molecularly distinct sarcoma types and the corresponding lack of suitable model systems.
Roland Imle, Daniel Blösel, Felix K. F. Kommoss, Sara Placke, Eric Stutheit-Zhao, Christina Blume, Dmitry Lupar, Lukas Schmitt, Claudia Winter, Lena Wagner, Malte von Eicke, Hannah Walzer, Julia Förderer, Stephanie Laier, Michael Hertwig, Heike Peterziel, Ina Oehme, Sophia Scheuerman, Christian M. Seitz, Florian H. Geyer, Florencia Cidre-Aranaz, Thomas G. P. Grünewald, Christian Vokuhl, Priya Chudasama, Claudia Scholl, Claudia Schmidt, Patrick Günther, Martin Sill, Kevin B. Jones, Stefan M. Pfister, Robert J. Autry, Ana Banito   +31 more
doaj   +1 more source

Choosing the right animal model for sarcoma research

Cellular and Molecular Life Sciences
Sarcomas comprise over 100 mesenchymal malignancies characterised by extreme genomic heterogeneity, ranging from fusion-driven paediatric tumours to highly unstable adult leiomyosarcomas. This genetic complexity shapes tumour behaviour, influences growth
Piotr Remiszewski, Eryk Siedlecki, Marlena Wełniak-Kamińska, Michał Mikula, Anna Czarnecka   +4 more
doaj   +1 more source

Mechanisms of Resistance to Anti-PD-1 Immunotherapy in Melanoma and Strategies to Overcome It

Biomolecules
Resistance to anti-PD-1 therapy in melanoma remains a major obstacle in achieving effective and durable treatment outcomes, highlighting the need to understand and address the underlying mechanisms.
Magdalena K. Zielińska, Magdalena Ciążyńska, Dorota Sulejczak, Piotr Rutkowski, Anna M. Czarnecka   +4 more
doaj   +1 more source

Clear Cell Sarcoma: A Case Report with Radiological and Pathological Features of an Atypical Case

Case Reports in Oncology, 2012
Clear cell sarcoma of soft tissue is a rare, aggressive soft tissue tumor, which is morphologically similar to malignant melanoma but has no precursor skin lesion and, instead, has a characteristic chromosomal translocation.
Bing Leng, Xinmin Zhang, Sayed Ali, Marc Karpo, Salil Singh, Robert Herpen, Paul J. Zhang, Jasvir S. Khurana   +7 more
doaj   +1 more source

Levels of activated platelet-derived microvesicles in patients with soft tissue sarcoma correlate with an increased risk of venous thromboembolism

BMC Cancer, 2017
Background Microvesicles are small vesicles expressing specific antigens from their cells of origin. Elevated levels of microvesicles have been shown to be associated with coagulation disorders as well as with different types of malignancies.
A. Fricke, P. V. Ullrich, A. F. V. Cimniak, C. Becherer, M. Follo, J. Heinz, J. Scholber, G. W. Herget, O. Hauschild, U. A. Wittel, G. B. Stark, H. Bannasch, D. Braig, S. U. Eisenhardt   +13 more
doaj   +1 more source

Pleomorphic sarcoma [PDF]

, 2013
67-year-old female who was referred from her general practitioner because of uncontrolled right popliteal knee pain which was very severe and continuously deteriorating. She could not bend her knee and sleep because of the pain.
Bertuello, Isaac, Bonnici, Maria
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