Results 41 to 50 of about 710,485 (229)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
It's written in the cloud: The hype and promise of cloud computing [PDF]
, 2010 Purpose of paper: This viewpoint discusses the emerging IT platform of Cloud Computing and discusses where and how this has developed in terms of the collision between internet and enterprise computing paradigms – and hence why cloud computing will be ...
Sharif, AM
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
CLOUD TECHNOLOGIES IN INNOVATIVE ACCOUNTING
Вестник Кемеровского государственного университета, 2013 Тhe research focuses on the innovations in accounting enabling to accumulate the resources of the organization more effectively, to reduce the costs associated with the acquisition of spare servers, etc.
R. T. Unshchikova, A. A. Ippolitowa
doaj
Computing Continuum Simulator: A comprehensive framework for continuum architecture evaluation
SoftwareXThe Computing Continuum paradigm is essential for meeting the needs of IoT applications that demand real-time processing, reliable connectivity, and low-latency response.
Pablo Rodríguez +5 more
doaj +1 more source
Proposed architecture for intrusion detection system for software as a service in cloud computing environment [PDF]
, 2015 The purpose of this paper is to propose an architecture for intrusion detection based on Software as a Service (SaaS) called Software as a Service Intrusion Detection Services (SaaSIDS) in a cloud environment.
Ahmed, Azuan +4 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Jurnal Teknologi Pendidikan, 2023 Merdeka Learning is one of the breakthroughs in education carried out by the Government of Indonesia. One form of activity from Merdeka Learning is student exchange.
Daniel Soesanto +3 more
doaj +1 more source
A Local Search Algorithm for Clustering in Software as a Service Networks [PDF]
, 2011 In this paper we present and analyze a model for clustering in networks that offer Software as a Service (SaaS). In this problem, organizations requesting a set of applications have to be assigned to clusters such that the costs of opening clusters and ...
Gaast, J.P. (Jelmer) van der +3 more
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