Results 81 to 90 of about 713,425 (307)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Feature placement algorithms for high-variability applications in cloud environments [PDF]

, 2012
While the use of cloud computing is on the rise, many obstacles to its adoption remain. One of the weaknesses of current cloud offerings is the difficulty of developing highly customizable applications while retaining the increased scalability and lower ...
De Turck, Filip, Dhoedt, Bart, Joosen, Wouter, Moens, Hendrik, Truyen, Eddy, Walraven, Stefan   +5 more
core   +1 more source

Design and evaluation of an architecture for future smart grid service provisioning [PDF]

, 2012
In recent years, there has been a growing interest in cloud technologies. Using current cloud solutions, it is however difficult to create customizable multi-tenant applications, especially if the application must support varying Quality of Service (QoS)
De Turck, Filip, Develder, Chris, Melis, Stijn, Mets, Kevin, Pollet, Thierry, Strobbe, Matthias, Van de Veire, Stijn, Verschueren, Tom   +7 more
core   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Software as a Service: Analyzing Security Issues

, 2014
International Conference on Big Data and Analytics for Business (BDAB 2014), New Delhi, India, Dec.
Chouhan, Pushpinder Kaur, Yao, Feng, Yerima, Suleiman, Sezer, Sakir   +3 more
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Coordination mechanism of SaaS service supply chain: Based on compensation contracts

Journal of Industrial Engineering and Management, 2013
Purpose: The purpose of this paper is to build new contracts theories of SaaS service supply chain. Software as a Service (SaaS) has become a hot topic in this industry .
Yanli Guo, Jianbin Chen, Hailing Guo, Xinman Lu   +3 more
doaj   +1 more source

DataV: Data Visualization on large high-resolution displays

Visual Informatics, 2020
In recent years, the technology and applications of visualizations on large high-resolution displays (LHDs) have received widespread attention because of its perceptual benefits and improved productivity. However, existing work on LHD visualization lacks
Honghui Mei, Huihua Guan, Chengye Xin, Xiao Wen, Wei Chen   +4 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A Local Search Algorithm for Clustering in Software as a Service Networks [PDF]

In this paper we present and analyze a model for clustering in networks that offer Software as a Service (SaaS). In this problem, organizations requesting a set of applications have to be assigned to clusters such that the costs of opening clusters and ...
Gaast, J.P. van der, Gabor, A.F., Rietveld, C.A., Zhang, Y.   +3 more
core   +1 more source