Results 91 to 100 of about 356,908 (270)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A Hybrid Routing Protocol for Wireless Distributed Networks

IEEE Access, 2018
Trends in networking are shifting from distributed to logically centralized networks. Software defined networking (SDN) is the key technology behind this shift.
Malik Najmus Siraj, Zaheer Ahmed, Muhammad Kashif Hanif, Muhammad Hasanain Chaudary, Shoab Ahmed Khan, Nadeem Javaid   +5 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Hardening Software Defined Networks [PDF]

, 2014
Abstract : Software Defined Networking (SDN) presents an extremely rare point of inflection which offers the potential to leverage the economics of SDN to harden the network as a whole. Utilizing this inflection point requires security technologies that have two characteristics.
Tim Kelley, Chris Small, Chris Hall, Zhi-Lang Zhang, Ander odlyzko, Ross Anderson, Jean Camp   +6 more
openaire   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Exposing End-to-End Delay in Software-Defined Networking

International Journal of Reconfigurable Computing, 2019
Software-Defined Networking (SDN) shows us a promising picture to deploy the demanding services in a fast and cost-effective way. Till now, most SDN use cases are deployed in enterprise/campus networks and data center networks. However, when applying SDN
Ting Zhang, Bin Liu
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Software-defined time-sensitive networking for hybrid multi-domain networking

Tongxin xuebao
To address the problem of deterministic end-to-end transmission in hybrid multi-domain networks, a software-defined time-sensitive network organization solution was proposed.
GUO Mengjie, SHOU Guochu, LIU Yaqiong, HU Yihong   +3 more
doaj  

A Survey on Software-Defined Wireless Sensor Networks: Challenges and Design Requirements

IEEE Access, 2017
Software defined networking (SDN) brings about innovation, simplicity in network management, and configuration in network computing. Traditional networks often lack the flexibility to bring into effect instant changes because of the rigidity of the ...
Hlabishi I. Kobo, Adnan M. Abu-Mahfouz, Gerhard P. Hancke   +2 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source