Results 101 to 110 of about 54,945 (291)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
, 2013 Overlay networking makes it easy for users add new network functionalities while keeping existing Internet connectivity intact. This paper introduces SCONE (Service-COmposable InterNEt) as a networking service to facilitate the management of service ...
조진용, 이소연
core
Practical extensions to countermeasure DoS attacks in software defined networking
, 2017 In this paper, we propose two simple and practically feasible countermeasures to address the Route Spoofing and Resource Exhaustion attacks in Software Defined Networking (SDN) scenarios.
Conti M. +4 more
core +1 more source
Software-Defined Time Sensitive Networks Configuration and Management
, 2021 Deterministic real time networking is typically provided by dedicated fieldbus networks which prevents innovation due to their proprietary nature, inflexibility and high-cost.
Hamza Chahed +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
On the security of software-defined next-generation cellular networks
, 2016 In the recent years, mobile cellular networks are ndergoing fundamental changes and many established concepts are being revisited. Future 5G network architectures will be designed to employ a wide range of new and emerging technologies such as Software ...
Vasilakis, Vasileios +4 more
core
Traffic engineering in software-defined networking: Measurement and management
IEEE Access, 2016 As the next generation network architecture, software-defined networking (SDN) has exciting application prospects. Its core idea is to separate the forwarding layer and control layer of network system, where network operators can program packet ...
Zhaogang Shu +6 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A Hybrid Routing Protocol for Wireless Distributed Networks
IEEE Access, 2018 Trends in networking are shifting from distributed to logically centralized networks. Software defined networking (SDN) is the key technology behind this shift.
Malik Najmus Siraj +5 more
doaj +1 more source