Results 61 to 70 of about 356,908 (270)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Self-Configuration Technology for Survivability Enhancement Oriented Software Defined Networking
Journal of Harbin University of Science and Technology, 2017 Software defined networking forwards the network control plane and data plane separation，and implements programming control centralized. In view of the resource allocation problem in software defined networking environments，self-configuration technology ...
WANG Jian +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
State of the art in software defined networking (SDN)
Visión Electrónica, 2019 The growth of networks at a global level is inevitable due to the increase of users, devices and applications, such as: Internet of Things (IoT), processing and analysis of large amounts of information (Big Data), or streaming audio and video, which has ...
Miguel Ángel Barrera Pérez +3 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Towards Quantum Satellite Internetworking: A Software-Defined Networking Perspective
IEEE Access, 2020 Recently, quantum computing and communications rapidly developed to interconnect heterogeneous quantum devices. In particular, some researchers have been performed about terrestrial quantum communications over typical optical fiber links.
Roberto Picchi +3 more
doaj +1 more source
Research and design of corporate networks infrastructure using SDN technologies with emphasis to virtual switch [PDF]
, 2016 Software Defined Networking has brought revolution to the world of Network technology which replaces most of the physical devices and control layer of the cloud computing reference model takes control of many Networking Devices.
Rahimi, M.
core
Field-Trial of Machine Learning-Assisted Quantum Key Distribution (QKD) Networking with SDN
, 2018 We demonstrated, for the first time, a machine-learning method to assist the coexistence between quantum and classical communication channels. Software-defined networking was used to successfully enable the key generation and transmission over a city and
Bi, Y. +8 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source