Results 71 to 80 of about 8,323,834 (282)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Software Defined Network-Based Multi-Access Edge Framework for Vehicular Networks
IEEE Access, 2020 Vehicular networks aim to support cooperative warning applications that involve the dissemination of warning messages to reach vehicles in a target area. Due to the high mobility of vehicles, imperative technologies such as software-defined network (SDN)
Lionel Nkenyereye +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A Novel Software-Defined Convolutional Neural Networks Accelerator
IEEE Access, 2019 The convolutional neural network (CNN) has been widely applied in computer vision applications. Due to the intensive computation, the general central processing unit (CPU) processors are not efficient to meet the real-time requirement.
Yufeng Li, Yankang Du
doaj +1 more source
OpenFlow Needs You! A Call for a Discussion About a Cleaner OpenFlow API [PDF]
, 2013 Software defined networks are poised to dramatically simplify deployment and management of networks. OpenFlow, in particular, is becoming popular and starts being deployed. While the definition of the “northbound” API that can be used by the new services
Kuzniar, Maciej +5 more
core +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Towards Dynamic Controller Placement in Software Defined Vehicular Networks
Sensors, 2020 The emerging SDVN (Software Defined Vehicular Network) paradigm promises to bring flexibility and efficient resource utilization to vehicular networks, enabling the emergence of novel Intelligent Transportation Services.
Soufian Toufga +4 more
doaj +1 more source
Fast Recovery in Software-Defined Networks
2014 Third European Workshop on Software Defined Networks, 2014 Although Software-Defined Networking and its implementation OpenFlow facilitate managing networks and enable dynamic network configuration, recovering from network failures in a timely manner remains non-trivial. The process of (a) detecting the failure, (b) communicating it to the controller and (c) recomputing the new shortest paths may result in an ...
Van Adrichem, N.L.M. (author) +2 more
openaire +5 more sources
Component Integrity Guarantees in Software-Defined Networking Infrastructure [PDF]
, 2017 Operating system level virtualization containers are commonly used to deploy virtual network functions (VNFs) which access the centralized network controller in software-defined net- working (SDN) infrastructure.
Nicolae Paladi +5 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source