Results 81 to 90 of about 1,453,224 (286)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Securing the SDN Data Plane in Emerging Technology Domains: A Review

Future Internet
Over the last decade, Software-Defined Networking (SDN) has garnered increasing research interest for networking and security. This interest stems from the programmability and dynamicity offered by SDN, as well as the growing importance of SDN as a ...
Travis Quinn, Faycal Bouhafs, Frank den Hartog   +2 more
doaj   +1 more source

Cognitive Routing in Software-Defined Underwater Acoustic Networks

Applied Sciences, 2017
There are two different types of primary users (natural acoustic and artificial acoustic), and there is a long propagation delay for acoustic links in underwater cognitive acoustic networks (UCANs). Thus, the selection of a stable route is one of the key
Huma Ghafoor, Insoo Koo
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Quantum-Aware Software Defined Networks [PDF]

, 2016
Software Defined Networks (SDN) represent a major paradigm change in communications networks. It provides a level of abstraction and independence from the traditional networking practice that allows for a fast path of innovation and, specifically, opens ...
Aguado, Alejandro, de la Iglesia, F., Gomez, M., Hugues Salas, Emilio, Lopez, D., Lord, A., Martin, V., Martinez-Mateo, J., Nejabati, Reza, Peev, M., Rosales, J.L., Simeonidou, Dimitra   +11 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Cache-Enabled Software Defined Heterogeneous Networks for Green and Flexible 5G Networks

IEEE Access, 2016
The network densification of small cells (SCs) is a promising way to cope with the explosive growth of future traffic demands in 5G networks. However, the overall power consumption and the backhaul limitation of the network have become the key factors ...
Jiaxin Zhang, Xing Zhang, Wenbo Wang
doaj   +1 more source

Disaster-Resilient Control Plane Design and Mapping in Software-Defined Networks

, 2015
Communication networks, such as core optical networks, heavily depend on their physical infrastructure, and hence they are vulnerable to man-made disasters, such as Electromagnetic Pulse (EMP) or Weapons of Mass Destruction (WMD) attacks, as well as to ...
Chowdhury, Pulak, Habib, M. Farhan, Mukherjee, Biswanath, Savas, S. Sedef, Tornatore, Massimo   +4 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Quantum-Key-Distribution (QKD) Networks Enabled by Software-Defined Networks (SDN)

Applied Sciences, 2019
As an important support for quantum communication, quantum key distribution (QKD) networks have achieved a relatively mature level of development, and they face higher requirements for multi-user end-to-end networking capabilities.
Hua Wang, Yongli Zhao, Avishek Nag
doaj   +1 more source