Results 101 to 110 of about 15,524,849 (357)

Evaluation of software dependability [PDF]

, 1996
It has been said that the term software engineering is an aspiration not a description. We would like to be able to claim that we engineer software, in the same sense that we engineer an aero-engine, but most of us would agree that this is not currently ...
Littlewood, B.
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Software para sistemas de concentración solar: validación experimental

Revista Científica de la UCSA
Este trabajo presenta avances en el desarrollo de un software de simulación para determinar parámetros termofísicos (Temperatura de salida, Potencia térmica, Energía térmica y Presión) en sistemas de concentración solar, enfocado en el suministro de ...
Hugo Aparicio, Pablo Dellicompagni, Carlos Cadena   +2 more
doaj   +1 more source

TASSEL: software for association mapping of complex traits in diverse samples

Bioinform., 2007
Association analyses that exploit the natural diversity of a genome to map at very high resolutions are becoming increasingly important. In most studies, however, researchers must contend with the confounding effects of both population and family ...
Peter J. Bradbury, Zhiwu Zhang, Dallas E. Kroon, T. Casstevens, Yogesh Ramdoss, E. Buckler   +5 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Software architectures and Open Source Software: Where can research leverage the most? [PDF]

, 2001
Software architectures have been playing a central role in software engineering research for some years now. They are considered of pivotal importance in the success of complex software systems development.
Arief, B., Gacek, C., Lawrie, T.
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Software and pipelines for registration and analyses of rodent brain image data in reference atlas space

Frontiers in Neuroinformatics
Advancements in methodologies for efficient large-scale acquisition of high-resolution serial microscopy image data have opened new possibilities for experimental studies of cellular and subcellular features across whole brains in animal models. There is
Maja A. Puchades, Sharon C. Yates, Gergely Csucs, Harry Carey, Arda Balkir, Trygve B. Leergaard, Jan G. Bjaalie   +6 more
doaj   +1 more source

Mediatized Skill: How Capabilities With Application Software Are Collectively Performed, Perceived, and Organized as Part of Contemporary Media Practices

International Journal of Communication, 2022
By combining elements from theories of media practice, genre, and mediatization, I argue that perceiving, performing, and organizing skills are interwoven with media, and such interweaving has important implications for the practical politics of ...
Frédérik Lesage
doaj  

Coordination in software development [PDF]

, 1995
Robert E. Kraut, Lynn A. Streeter
openalex   +1 more source