Results 91 to 100 of about 4,685,278 (250)

Reliability of 2D motion analysis software for evaluation of dynamic smile asymmetry using smartphone technology

Clinical and Investigative Orthodontics
Aim To evaluate the reliability of a free motion analysis method in the evaluation of the 2D dynamic asymmetry of smiles using smartphone technology.Materials and methods Twenty-six healthy adult females were included in this study. Four facial bilateral
Dhelal Al-Rudainy, Hadeel Adel Al-Lami, Talib Al-Ameri, Liu Yang   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Una visión a la propuesta de Arquitectura Dirigida por Modelos

Revista UNIMAR, 2016
Este documento presenta un acercamiento a la iniciática Model Driven Architecture (MDA, Arquitectura Dirigida por Modelos) propuesta por Object Management Group (OMG). MDA separa la lógica de la aplicación del negocio.
Luis Muñoz, Guillermo Solarte, Douglas Hernández Heredia   +2 more
doaj  

ReSurfEMG: A Python Package for Comprehensive Analysis of Respiratory Surface EMG

Sensors
In patients with respiratory failure, mechanical ventilation aims to balance respiratory muscle loading and gas exchange. The interplay between the ventilator and the respiratory muscles is an increasingly recognized factor in tailoring ventilatory ...
Robertus Simon Petrus Warnaar, Candace Makeda Moore, Walter Baccinelli, Farnaz Soleimani, Dirk Wilhelm Donker, Eline Oppersma   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Artifical Intelligence and the End of the Author

Umanistica Digitale
Although artificial intelligence and generative artificial intelligence have outstanding achievements, evaluating their possibilities and drawbacks is still problematic.
Umberto Roncoroni
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Poor Quality of Small Bowel Capsule Endoscopy Images Has a Significant Negative Effect in the Diagnosis of Small Bowel Malignancy

Clinical and Experimental Gastroenterology, 2020
Diana E Yung,1 John N Plevris,1 Romain Leenhardt,2 Xavier Dray,2 Anastasios Koulaouzidis1 On behalf of the ESGE Small Bowel Research Working Group1Centre for Liver and Digestive Disorders, The Royal Infirmary of Edinburgh, Edinburgh, UK; 2Sorbonne ...
Yung DE, Plevris JN, Leenhardt R, Dray X, Koulaouzidis A   +4 more
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