Results 101 to 110 of about 6,785,044 (298)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Creating a Computing Programs Package to Aid in the Assessment and Prognosis of Patients Suffering from Cerebrovascular Diseases

open access: yesMedisur, 2007
Fundament: The have an evaluation and prognosis of patients suffering from cerebrovascular diseases in its acute phase is important in order to define the medical management as well as others several aspects.
Carlos Jaime Geroy Gómez   +4 more
doaj  

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

open access: yesFEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez   +2 more
wiley   +1 more source

Six Years of Evaluating Software Architectures in Student Projects [PDF]

open access: yes, 2007
Software architecture evaluations are an important decision support tool when developing software systems. It is thus important that they are conducted professionally and that the results are of high quality.
Svahnberg, Mikael, Mårtensson, Frans
core   +1 more source

Software livre de produção textual com predição de palavras: um aliado do aluno especial Text production with a word predicition free-ware software: support for the special student

open access: yesRevista Brasileira de Educação Especial, 2009
A dificuldade em comunicar-se naturalmente, seja através da fala ou da escrita, pode fazer com que uma pessoa seja impedida de demonstrar e desenvolver seus potenciais cognitivos, sociais e criativos. Essa realidade tem sido amplamente estudada, buscando
Monica Jordan   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Characterization of security defects and analysis of vulnerability criticality in software for automated systems of internal affairs bodies

open access: yesВестник Дагестанского государственного технического университета: Технические науки
Objective. The purpose of the study is to theoretically analyze security defects and study the criticality of vulnerabilities in software used in modern automated systems of internal affairs agencies.Method.
I. G. Drovnikova, A. D. Popova
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Ducque model builder software [PDF]

open access: yes
The source code of the model builder ...
Jérôme Rihon (17025675)
core   +1 more source

Heron, a Knowledge Graph editor for intuitive implementation of Python-based experimental pipelines

open access: yeseLife
To realise a research project, experimenters face conflicting design and implementation choices across hardware and software. These include balancing ease of implementation – time, expertise, and resources – against future flexibility, the number of ...
George Dimitriadis   +3 more
doaj   +1 more source

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