Results 111 to 120 of about 12,387,075 (264)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

TwinP2G: A Software Application for Optimal Power-to-Gas Planning

Future Internet
This paper presents TwinP2G, a software application for optimal planning of investments in power-to-gas (PtG) systems. TwinP2G provides simulation and optimization services for the techno-economic analysis of user-customized energy networks.
Eugenia Skepetari, Sotiris Pelekis, Hercules Koutalidis, Alexandros Menelaos Tzortzis, Georgios Kormpakis, Christos Ntanos, Dimitris Askounis   +6 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Una visión a la propuesta de Arquitectura Dirigida por Modelos

Revista UNIMAR, 2016
Este documento presenta un acercamiento a la iniciática Model Driven Architecture (MDA, Arquitectura Dirigida por Modelos) propuesta por Object Management Group (OMG). MDA separa la lógica de la aplicación del negocio.
Luis Muñoz, Guillermo Solarte, Douglas Hernández Heredia   +2 more
doaj  

Reliability of 2D motion analysis software for evaluation of dynamic smile asymmetry using smartphone technology

Clinical and Investigative Orthodontics
Aim To evaluate the reliability of a free motion analysis method in the evaluation of the 2D dynamic asymmetry of smiles using smartphone technology.Materials and methods Twenty-six healthy adult females were included in this study. Four facial bilateral
Dhelal Al-Rudainy, Hadeel Adel Al-Lami, Talib Al-Ameri, Liu Yang   +3 more
doaj   +1 more source

Software portability [PDF]

, 1986
This thesis represents the submission to the Open University for the degree of Master of Philosophy. The research topic lies within the discipline of computer science and in particular problems associated with the transportability of computer software are investigated.
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

ReSurfEMG: A Python Package for Comprehensive Analysis of Respiratory Surface EMG

Sensors
In patients with respiratory failure, mechanical ventilation aims to balance respiratory muscle loading and gas exchange. The interplay between the ventilator and the respiratory muscles is an increasingly recognized factor in tailoring ventilatory ...
Robertus Simon Petrus Warnaar, Candace Makeda Moore, Walter Baccinelli, Farnaz Soleimani, Dirk Wilhelm Donker, Eline Oppersma   +5 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Artifical Intelligence and the End of the Author

Umanistica Digitale
Although artificial intelligence and generative artificial intelligence have outstanding achievements, evaluating their possibilities and drawbacks is still problematic.
Umberto Roncoroni
doaj   +1 more source