Results 91 to 100 of about 1,614,546 (322)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A Multimodal Software Architecture for Serious Exergames and Its Use in Respiratory Rehabilitation. [PDF]

Sensors (Basel), 2023
Dias C, Nery JTC, Hounsell MDS, Leal AB.
europepmc   +1 more source

Factors Affecting Architectural Decision-Making Process and Challenges in Software Projects: A Survey with Architecture Experts and Practitioners

, 2022
Merve Özdeş, Oumout Chouseinoglou, Ayça Kolukısa Tarhan   +2 more
openalex   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Software Architecture. [PDF]

The Journal of Object Technology, 2004
openaire   +2 more sources

An architecture-based dependability modeling framework using AADL [PDF]

, 2006
For efficiency reasons, the software system designers' will is to use an integrated set of methods and tools to describe specifications and designs, and also to perform analyses such as dependability, schedulability and performance.
Kaaniche, Mohamed, Kanoun, Karama, Rugina, Ana-Elena   +2 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

SHEPHARD: a modular and extensible software architecture for analyzing and annotating large protein datasets. [PDF]

Bioinformatics, 2023
Ginell GM, Flynn AJ, Holehouse AS.
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Software architecture for pervasive critical health monitoring system using fog computing. [PDF]

J Cloud Comput (Heidelb), 2022
Ilyas A, Alatawi MN, Hamid Y, Mahfooz S, Zada I, Gohar N, Shah MA.   +6 more
europepmc   +1 more source