Results 71 to 80 of about 1,614,546 (322)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

A Few-Shot Learning-Based Point Cloud Semantic Segmentation Network for Tunnel Lining Inspection

IET Signal Processing
Next-generation 6G networks will significantly advance the development of integrated sensing, communication, and computing (ISSC) systems, particularly in collection and processing of point cloud data.
Ziyi Li, Nan Jiang, Lihong Tong
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

User interface development and software environments : the Chiron-1 system [PDF]

, 1990
User interface development systems for software environments have to cope with the broad, extensible and dynamic character of such environments, must support internal and external integration, and should enable various software development strategies ...
Cameron, Mary, Keller, Rudolf K., Taylor, Richard N., Troup, Dennis B.   +3 more
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Multilingual Source Code Analysis: A Systematic Literature Review

IEEE Access, 2017
Contemporary software applications are developed using cross-language artifacts, which are interdependent with each other. The source code analysis of these applications requires the extraction and examination of artifacts, which are build using multiple
Zaigham Mushtaq, Ghulam Rasool, Balawal Shehzad   +2 more
doaj   +1 more source

One-Chip Solution to Intelligent Robot Control: Implementing Hexapod Subsumption Architecture Using a Contemporary Microprocessor

, 2004
This paper introduces a six-legged autonomous robot managed by a single controller and a software core modeled on subsumption architecture. We begin by discussing the features and capabilities of IsoPod, a new processor for robotics which has enabled a ...
Iwamasa, Ryuichi, Pashenkov, Nikita
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A Trustworthiness Evaluation Method for Software Architectures Based on the Principle of Maximum Entropy (POME) and the Grey Decision-Making Method (GDMM)

Entropy, 2014
As the early design decision-making structure, a software architecture plays a key role in the final software product quality and the whole project.
Rong Jiang
doaj   +1 more source

A Game of Attribute Decomposition for Software Architecture Design

, 2015
Attribute-driven software architecture design aims to provide decision support by taking into account the quality attributes of softwares. A central question in this process is: What architecture design best fulfills the desirable software requirements ...
A Bogomolnaia, CH Lung, D Garlan, K Wiegers, L Bass, L Zhu, LJ Bass, R Branzei, S Banerjee, T Roughgarden, Y Shoham   +10 more
core   +1 more source