Results 51 to 60 of about 5,174,549 (302)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

A multi-layered software architecture model for building software solutions in an urbanized information system

International Journal of Information Systems and Project Management, 2022
The concept of Information Systems urbanization has been proposed since the late 1990’s in order to help organizations building agile information systems. Nevertheless, despite the advantages of this concept, it remains too descriptive and presents many
Sana Bent Aboulkacem Guetat, Salem Ben Dhaou Dakhli   +1 more
doaj  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

An Architecture Assessment Model: Holistic Evaluation of Software Architecture

IEEE Access
Current architecture review methods predominantly focus on verifying compliance between design and requirements, as well as between code and design. However, they often overlook whether the final product has been adequately tested against architecturally
Mujdat Bayar, Onur Taviloglu, Ahmet Unudulmaz, Yavuz Gunes, Koray Dogutekin   +4 more
doaj   +1 more source

Replication Package of "evaluation Methods and Replicability of Software Architecture Research Objects"

, 2022
58In "Evaluation Methods and Replicability of Software Architecture Research"[1], we present a systematic literature review to assess the state-of-practice of evaluating software architecture research objects and providing replication artifacts in 153 ...
Jürjens, Jan, Großer, K., Heinrich, R., Al-Doori, M., Hahner, S., Schulz, S., Koziolek, A., Kühn, T., Reussner, R., Ehl, M., Fuchß, D., Keim, J., Töberg, J.-P., Konersmann, M., Boltz, N., Lohr, M., Kaplan, A., Sağlam, T.   +17 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

LITERATURE REVIEW IOT SOFTWARE ARCHITECTURE ON AGRICULTURE

JUTI: Jurnal Ilmiah Teknologi Informasi, 2021
Context – Internet of Things (IoT) interrelates computing devices, machines, animals, or people and things that use the power of internet usage to utilize data to be much more usable.
Junaidi Junaidi, Amirullah Andi Bramantya, Bintang Satya Pradipta   +2 more
doaj   +1 more source

Accuracy Test of Software Architecture Compliance Checking Tools – Test Instruction [PDF]

, 2015
Software Architecture Compliance Checking (SACC) is an approach to verify conformance of implemented program code to high-level models of architectural design.
Brinkkemper., Sjaak, Pruijt, Leo, Software Production, van der Werf, J.M.E.M., Sub Software Production   +4 more
core  

Early performance testing of distributed software applications [PDF]

, 2004
Performance characteristics, such as response time, throughput and scalability, are key quality attributes of distributed applications. Current practice, however, rarely applies systematic techniques to evaluate performance characteristics. We argue that
Giovanni Denaro, Denaro, G, DENARO GIOVANNI, Polini, A, EMMERICH WOLFGANG, Wolfgang Emmerich, POLINI, Andrea, Emmerich, W, Andrea Polini   +8 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source