Results 31 to 40 of about 541,753 (313)

Software Architecture Degradation in Open Source Software: A Systematic Literature Review

open access: yesIEEE Access, 2020
Software architecture (SA) has a prominent role in all stages of system development. Given the persistent evolution of software systems over time, SA tends to be eroded or degraded. Such phenomenon is called architectural degradation.
Ahmed Baabad   +3 more
doaj   +1 more source

A Process for Monitoring the Impact of Architecture Principles on Sustainability: An Industrial Case Study

open access: yesSoftware
Architecture principles affect a software system holistically. Given their alignment with a business strategy, they should be incorporated within the validation process covering aspects of sustainability. However, current research discusses the influence
Markus Funke   +3 more
doaj   +1 more source

An active-architecture approach to COTS integration

open access: yes, 2011
Commercial off-the-shelf (COTS) software products are increasingly used as standard components within integrated information systems. This creates challenges since both their developers and source code are not usually available, and the ongoing ...
Balasubramaniam, Dharini   +8 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Estimation of the manoeuvrability of the KVLCC2 in calm water using free running simulation based on CFD

open access: yesInternational Journal of Naval Architecture and Ocean Engineering, 2021
There are three different well-known methods for predicting the manoeuvrability of ships: (1) free running model test, (2) direct manoeuvring simulation using CFD and (3) system-based manoeuvring simulation.
In-Tae Kim   +7 more
doaj   +1 more source

Software architecture visualisation [PDF]

open access: yes, 2004
Tracing the history of software engineering reveals a series of abstractions. In early days, software engineers would construct software using machine code.
Hatch, Andrew
core  

Dominion : an architecture-driven approach to generating efficient constraint solvers

open access: yes, 2011
This work is supported by the EPSRC grant “A Constraint Solver Synthesiser” (EP/H004092/1) and SICSA studentships.Constraints are used to solve combinatorial problems in a variety of industrial and academic disciplines.
Balasubramaniam, Dharini   +11 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Preliminary Studies to Bridge the Gap: Leveraging Informal Software Architecture Artifacts for Structured Model Creation

open access: yesInformation
This study addresses the prevalent gap between structured models and informal architectural methodologies in software engineering. Recognizing the potential of informal architecture artifacts in analytical processes, we introduce a methodology that ...
Joshua Kaplan, Luis Rabelo
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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