Results 61 to 70 of about 541,753 (313)
Architecture reconstruction and analysis of medical device software
, 2022 S.194-203New research is underway at the FDA to investigate the benefits of integrating architecture analysis into safety evaluations of medical-device software.
Jones, P. +5 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Software Architecture of Manufacturing Execution Systems [PDF]
Journal of Systemics, Cybernetics and Informatics, 2010 The globalization of the economy and the associated factors of increasing effectiveness in production, shortening innovation cycles, safeguarding high quality, etc. are continually augmenting the pressure on the production business.
Heiko Meyer
doaj
A reflective architecture to support dynamic software evolution [PDF]
, 2002 This thesis presents work which is concerned with the run-time evolution of component-based software systems. In particular, the main result of the research presented here is a framework which is used to model and control the architecture of a software ...
Rank, Stephen
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
IEEE Access, 2019 Delivering better flight software is an important concern to improve CubeSat missions success. It has been identified as a key element to enhance team collaboration, increase reusability, reduce the mission risk, and facilitate the development and ...
Carlos E. Gonzalez +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Multilingual Source Code Analysis: A Systematic Literature Review
IEEE Access, 2017 Contemporary software applications are developed using cross-language artifacts, which are interdependent with each other. The source code analysis of these applications requires the extraction and examination of artifacts, which are build using multiple
Zaigham Mushtaq +2 more
doaj +1 more source