Results 61 to 70 of about 5,174,549 (302)
Software-Architecture Recovery from Machine Code [PDF]
, 2013 In this paper, we present a tool, called Lego, which recovers object-oriented software architecture from stripped binaries. Lego takes a stripped binary as input, and uses information obtained from dynamic analysis to (i) group the functions in the ...
Srinivasan, Venkatesh Karthik +1 more
core
From EAST-ADL to AUTOSAR Software Architecture: A Mapping Scheme
, 2011 This paper addresses the gap between models describing system requirements, functions and architecture at a higher level of abstraction (such as SysML models), with respect to software/hardware architecture description (such as the AADL models) as the ...
Henrik Lönn +7 more
core +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
IEEE Access, 2019 Delivering better flight software is an important concern to improve CubeSat missions success. It has been identified as a key element to enhance team collaboration, increase reusability, reduce the mission risk, and facilitate the development and ...
Carlos E. Gonzalez +3 more
doaj +1 more source
Adaptation and software architecture [PDF]
Proceedings of the third international workshop on Software architecture, 1998 1. ABSTRACT This paper focuses on the need to adapt software components and software architectures. Too often, examples from the literature avoid the difficult problem of constructing a software system from sets of (possibly independently constructed) software components. Consider the following example: given a set of components, an application builder
openaire +2 more sources
Architecture reconstruction and analysis of medical device software
, 2022 S.194-203New research is underway at the FDA to investigate the benefits of integrating architecture analysis into safety evaluations of medical-device software.
Jones, P. +5 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Software architecture for managing the Fisheries ontologies lifecycle [PDF]
, 2007 This document describes the software architecture for implementing a system for managing the fisheries ontologies lifecycle, cornerstone of WP7. The lifecycle described in this deliverable is an instantiation of the possible lifecycles that can be ...
Soonho, Kim +8 more
core +1 more source