Results 21 to 30 of about 404,314 (226)

A Clustering Approach to Identify Risk Perception on Social Networks: A Study of Peruvian Children and Adolescents

Informatics
The excessive and inappropriate use of the internet by children and young people increases their exposure to risky situations, especially since the COVID-19 pandemic.
Yasiel Pérez Vera, Richart Smith Escobedo Quispe, Patrick Andrés Ramírez Santos   +2 more
doaj   +1 more source

Software Architecture Degradation in Open Source Software: A Systematic Literature Review

IEEE Access, 2020
Software architecture (SA) has a prominent role in all stages of system development. Given the persistent evolution of software systems over time, SA tends to be eroded or degraded. Such phenomenon is called architectural degradation.
Ahmed Baabad, Hazura Binti Zulzalil, Sa'adah Hassan, Salmi Binti Baharom   +3 more
doaj   +1 more source

A Process for Monitoring the Impact of Architecture Principles on Sustainability: An Industrial Case Study

Software
Architecture principles affect a software system holistically. Given their alignment with a business strategy, they should be incorporated within the validation process covering aspects of sustainability. However, current research discusses the influence
Markus Funke, Patricia Lago, Roberto Verdecchia, Roel Donker   +3 more
doaj   +1 more source

Estimation of the manoeuvrability of the KVLCC2 in calm water using free running simulation based on CFD

International Journal of Naval Architecture and Ocean Engineering, 2021
There are three different well-known methods for predicting the manoeuvrability of ships: (1) free running model test, (2) direct manoeuvring simulation using CFD and (3) system-based manoeuvring simulation.
In-Tae Kim, Cheolho Kim, Sang-Hyun Kim, Donghyeong Ko, Seong-Ho Moon, Hwanghi Park, Jaewoong Kwon, Bongyong Jin   +7 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Preliminary Studies to Bridge the Gap: Leveraging Informal Software Architecture Artifacts for Structured Model Creation

Information
This study addresses the prevalent gap between structured models and informal architectural methodologies in software engineering. Recognizing the potential of informal architecture artifacts in analytical processes, we introduce a methodology that ...
Joshua Kaplan, Luis Rabelo
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

LITERATURE REVIEW IOT SOFTWARE ARCHITECTURE ON AGRICULTURE

JUTI: Jurnal Ilmiah Teknologi Informasi, 2021
Context – Internet of Things (IoT) interrelates computing devices, machines, animals, or people and things that use the power of internet usage to utilize data to be much more usable. Food is one of the mandatory human needs to survive, and most of it is
Junaidi Junaidi, Amirullah Andi Bramantya, Bintang Satya Pradipta   +2 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source