Results 31 to 40 of about 404,314 (226)

Software-Defined Metaverse (SDM) Architecture

Journal of Metaverse
The metaverse, a vast virtual shared space that integrates enhanced physical reality with persistent virtual environments, has the potential to revolutionize digital interaction by providing deeply immersive and interactive experiences.
Ahmed Shalaby, Mazen Selim, Noha Abd Elkareem   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Context-Aware Expert for Software Architecture Recovery (CAESAR): An automated approach for recovering software architectures

Journal of King Saud University: Computer and Information Sciences, 2023
Software architecture recovery approaches help to reconstruct the architecture of complex software systems. However, the manual effort and expertise required to use such techniques are high, as the user demands detailed knowledge about software ...
Khaled Ibrahim, Hesham Hassan, Khaled T. Wassif, Soha Makady   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An Architecture Assessment Model: Holistic Evaluation of Software Architecture

IEEE Access
Current architecture review methods predominantly focus on verifying compliance between design and requirements, as well as between code and design. However, they often overlook whether the final product has been adequately tested against architecturally
Mujdat Bayar, Onur Taviloglu, Ahmet Unudulmaz, Yavuz Gunes, Koray Dogutekin   +4 more
doaj   +1 more source

A multi-layered software architecture model for building software solutions in an urbanized information system

International Journal of Information Systems and Project Management, 2013
The concept of Information Systems urbanization has been proposed since the late 1990’s in order to help organizations building agile information systems.
Sana Guetat, Salem Dakhli, , ,
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A multi-layered software architecture model for building software solutions in an urbanized information system

International Journal of Information Systems and Project Management, 2022
The concept of Information Systems urbanization has been proposed since the late 1990’s in order to help organizations building agile information systems. Nevertheless, despite the advantages of this concept, it remains too descriptive and presents many
Sana Bent Aboulkacem Guetat, Salem Ben Dhaou Dakhli   +1 more
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source