Results 101 to 110 of about 2,657,708 (305)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A Systematic Mapping Study of MMOG Backend Architectures
Information, 2019 The advent of utility computing has revolutionized almost every sector of traditionalsoftware development. Especially commercial cloud computing services, pioneered by the likesof Amazon, Google and Microsoft, have provided an unprecedented opportunity ...
Nearchos Paspallis, Nicos Kasenides
doaj +1 more source
Semantic annotation, publication, and discovery of Java software components: an integrated approach [PDF]
, 2009 Component-based software development has matured into standard practice in software engineering. Among the advantages of reusing software modules are lower costs, faster development, more manageable code, increased productivity, and improved software ...
Dranidis, Dimitris +2 more
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Software variability in service robotics. [PDF]
Empir Softw Eng, 2023 García S +5 more
europepmc +1 more source
Financial Software as a Service [PDF]
, 2014 Software as a service as one of the cloud delivery models that supports fine-grained components. Financial applications demand better performance and accuracy in a cloud than the traditional computing platforms. Therefore, designing financial software as a service (FSaaS) requires an engineering and systematic approach.
Ramachandran, M, Chang, V
openaire
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Technological development trends: Application service model (ASP) or 'Cloud Computing' [PDF]
Anali Ekonomskog fakulteta u Subotici, 2014 The paper discusses modern technological approaches and Internet concepts that are significantly and rapidly changing the view of the global business world.
Trninić Jelica, Đurković Jovica
doaj
Sourcing Lifecycle for Software as a Service (SAAS)
EPJ Web of Conferences, 2014 In recent years, Software as a Service (SaaS) has changed from curiosity caused concept to an accepted well known concept. A key advantage of this model is that, by cautious engineering, it is possible to influence economy of scale to decrease total cost
Santy , Sikkel K.
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source