Results 121 to 130 of about 2,092,569 (323)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Application of JKSimBlast software in drifting operations [PDF]

Podzemni Radovi, 2019
This paper presents a review of the advantages of application of JKSimBlast 2DFace software in design phase of underground premises. The aim of this research was to show possibilities of the software and possibility of its application in design of ...
Crnogorac Luka, Tokalić Rade, Lutovac Suzana, Gligorić Miloš, Ganić Aleksandar   +4 more
doaj  

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

A case study on integrating data analysis and process mining in conventional tunnel construction

Developments in the Built Environment
Conventional tunnel construction often relies on manual methods of construction process analysis, using tools such as paper-based cycle diagrams or spreadsheets, which lack immediate updates and capabilities, limiting performance evaluation ...
Oleksandr Melnyk, Marco Huymajer, Christian Huemer, Lucas Rosenberger, Alexandra Mazak-Huemer   +4 more
doaj   +1 more source

Construction of Evaluation Criteria and Module for Industrial Software [PDF]

, 2008
Byung-Tae Lee, Hae-Sool Yang
openalex   +1 more source

A Logic-based Framework for Software Construction

Journal of King Saud University - Computer and Information Sciences, 1997
AbstractThis paper describes a framework for assisting the automatic construction of programs from separately designed and compiled modules. The framework has facilities to automatically extract many important items of information from source codes. It has also facilities to deduce new items from old ones. The framework also supports multiple versions,
openaire   +2 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Interactive Construction of Solids from Orthographic Multiviews for an Educational Software Tool [PDF]

, 2009
Yong S. Suh, Johnathen McCasland
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

A software framework for construction of process-based stochastic spatio-temporal models and data assimilation [PDF]

, 2009
Derek Karssenberg, Oliver Schmitz, Peter Salamon, Kor de Jong, Marc F. P. Bierkens   +4 more
openalex   +1 more source