Results 71 to 80 of about 8,323,849 (282)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
COMPARATIVE ANALYSIS OF SOFTWARE DEFINED NETWORKS (SDN) AND CONVENTIONAL NETWORKS USING ROUTING PROTOCOLS [PDF]
, 2017 Conventional routing protocols such as RIP, OSPF, EIGRP and BGP have a very rigid and intricate system thus narrowing the adaptability of networks to the ever changing Internet, the emergence of Software Defined Networking (SDN) provides a solution for ...
Gopi, Deepthi
core
Software Defined Network-Based Multi-Access Edge Framework for Vehicular Networks
IEEE Access, 2020 Vehicular networks aim to support cooperative warning applications that involve the dissemination of warning messages to reach vehicles in a target area. Due to the high mobility of vehicles, imperative technologies such as software-defined network (SDN)
Lionel Nkenyereye +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A Novel Software-Defined Convolutional Neural Networks Accelerator
IEEE Access, 2019 The convolutional neural network (CNN) has been widely applied in computer vision applications. Due to the intensive computation, the general central processing unit (CPU) processors are not efficient to meet the real-time requirement.
Yufeng Li, Yankang Du
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
OpenFlow Needs You! A Call for a Discussion About a Cleaner OpenFlow API [PDF]
, 2013 Software defined networks are poised to dramatically simplify deployment and management of networks. OpenFlow, in particular, is becoming popular and starts being deployed. While the definition of the “northbound” API that can be used by the new services
Kuzniar, Maciej +5 more
core +2 more sources
Towards Dynamic Controller Placement in Software Defined Vehicular Networks
Sensors, 2020 The emerging SDVN (Software Defined Vehicular Network) paradigm promises to bring flexibility and efficient resource utilization to vehicular networks, enabling the emergence of novel Intelligent Transportation Services.
Soufian Toufga +4 more
doaj +1 more source
A Reo Model of Software Defined Networks [PDF]
, 2019 Reo is a compositional coordination language for component connectors with a formal semantics based on automata. In this paper, we propose a formal model of software defined networks (SDNs) based on Reo where declarative constructs comprising of basic Reo primitives compose to specify descriptive models of both data and control planes of SDNs. We first
H. Feng (Hui) +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source