Results 101 to 110 of about 7,103,185 (329)

An ontology of agile aspect oriented software development [PDF]

, 2011
Both agile methods and aspect oriented programming (AOP) have emerged in recent years as new paradigms in software development. Both promise to free the process of building software systems from some of the constraints of more traditional approaches.
Parsons, David
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Effects of Sensor Location on Dynamic Load Estimation in Weigh-in-Motion System

Sensors, 2018
In recent years, weigh-in-motion systems based on embedded sensor networks have received a lot of attention. However, how to improve the accuracy of multi-sensor weigh-in-motion (WIM) systems while keeping costs low remains a challenge.
Tianhao Qin, Mengxiang Lin, Ming Cao, Kaiya Fu, Rong Ding   +4 more
doaj   +1 more source

Rationale in Development Chat Messages: An Exploratory Study

, 2017
Chat messages of development teams play an increasingly significant role in software development, having replaced emails in some cases. Chat messages contain information about discussed issues, considered alternatives and argumentation leading to the ...
Alkadhi, Rana, Bruegge, Bernd, Guzman, Emitza, Lata, Teodora   +3 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

A reinforcement learning algorithm to optimize resource utilization in combat casualty care

Scientific Reports
Fluid resuscitation immediately following a hemorrhagic injury improves clinical outcome. However, future military conflicts are expected to result in mass-casualty incidents with limited availability of fluid-resuscitation resources.
Manivannan Subramaniyan, Xin Jin, Sridevi Nagaraja, Anders Wallqvist, Jaques Reifman   +4 more
doaj   +1 more source

Machine Learning and Deep Learning Methods for Intrusion Detection Systems: A Survey

Applied Sciences, 2019
Networks play important roles in modern life, and cyber security has become a vital research area. An intrusion detection system (IDS) which is an important cyber security technique, monitors the state of software and hardware running in the network ...
Hongyu Liu, Bo Lang
doaj   +1 more source

Research Article Software Component Selection Based on Quality Criteria Using the Analytic Network Process [PDF]

, 2014
Component based software development (CBSD) endeavors to deliver cost-effective and quality software systems through the selection and integration of commercially available software components.
Ali, Muhammad, Amin, Rohul, Anwar, Sajid, Cosmas, John, Lazaridis, Pavlos, Nawaz, Muhammad, Nazir, Shah, Shahzad, Sara, Sher Afzal, Khan   +8 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source