Results 91 to 100 of about 3,419,394 (318)

Behavior Modeling on ARINC653 to Support the Temporal Verification of Conformed Application Design

IEEE Access, 2019
Numerous factors have an impact on the temporal correction of integrated modular avionics application. As early as in the design phase, verification should be conducted to guarantee the rigorous temporal requirements for safety consideration which are ...
Kui Zhang, Ji Wu, Chao Liu, Syed Sarmad Ali, Jian Ren   +4 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Aid for Trade Report 2017

, 2017
Aid for Trade (AfT) seeks to support developing countries as they strengthen trade capacity and infrastructure. As the World Trade Organization’s main institutional counterpart for AfT in LAC, the Inter-American Development Bank (IDB) remains committed ...
Inter-American Development Bank
core   +1 more source

Maximizing the value of the software development process by game theoretic analysis [PDF]

, 2010
In this paper, we introduce the novel approach of employing the economic mechanism design concept in the software development process, and investigate methods to create and adjust the incentives and disincentives of the process and align them with the ...
O'Connor, Rory, O'Connor, Rory V., Yilmaz, Murat, O\u27Connor, Rory, Rory V. O'Connor, Murat Yilmaz, Murat Yilmaz (58709), Rory V. O'Connor (12588769)   +7 more
core   +1 more source

BioRel: towards large-scale biomedical relation extraction

BMC Bioinformatics, 2020
Background Although biomedical publications and literature are growing rapidly, there still lacks structured knowledge that can be easily processed by computer programs.
Rui Xing, Jie Luo, Tengwei Song
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Improving software development process through economic mechanism design [PDF]

, 2010
We introduce the novel concept of applying economic mechanism design to software development process, and aim to find ways to adjust the incentives and disincentives of the software organization to align them with the motivations of the participants in ...
Collins, John, O\u27Connor, Rory V., O\u27Connor, Rory, J.J. Collins (6931160), Murat Yilmaz, O'Connor, Rory, O'Connor, Rory V., Yilmaz, Murat, Rory V. O’Connor, John Collins, Collins, J.J., Murat Yilmaz (58709), Rory V. O'Connor (12588769)   +12 more
core   +1 more source

Machine learning model for predicting cyber-criminal characteristics

Kuwait Journal of Science
This study aims to predict investigation outcomes of individual cybercrime cases using the most relevant information provided by complainants. We curated a dataset on solved hacking cases from 2019 to 2022 from the cyber-crime combating department (3CD ...
Hesham A. Almansouri, Mohammad M. Khajah, Nasser B. Alsnayen   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source