Results 101 to 110 of about 20,143,612 (313)
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Behavior Modeling on ARINC653 to Support the Temporal Verification of Conformed Application Design
IEEE Access, 2019 Numerous factors have an impact on the temporal correction of integrated modular avionics application. As early as in the design phase, verification should be conducted to guarantee the rigorous temporal requirements for safety consideration which are ...
Kui Zhang +4 more
doaj +1 more source
BioRel: towards large-scale biomedical relation extraction
BMC Bioinformatics, 2020 Background Although biomedical publications and literature are growing rapidly, there still lacks structured knowledge that can be easily processed by computer programs.
Rui Xing, Jie Luo, Tengwei Song
doaj +1 more source
Challenging Inequalities: Our Early Childhood Development Sector Framework Document at a Glance
Investing in the first five years of life is essential for early childhood development (ECD) and contributes to increasing societal productivity, reducing poverty, and promoting equality.
Inter-American Development Bank
core +1 more source
IDB News: Vol. 2. no. 9, October 1975
, 1975 IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
IDB News: Vol. 2, no. 11, December 1975
, 1975 IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
IDB News: Vol. 3, no. 4, May 1976
, 1976 IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source