Results 111 to 120 of about 4,371,078 (240)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Interdependent figure-of-merit software development [PDF]
This program was undertaken in order to understand the complex nature of interdependent performance in space missions. At the first step in a planned sequence of progress, a spread sheet program was developed to evaluate different fuel/oxidizer ...
Kirsch, T., Ramohalli, K.
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Hierarchically Coupled View-Crossing Contrastive Learning for Knowledge Enhanced Recommendation
IEEE AccessKnowledge enhanced recommendation algorithms focus on how to leverage auxiliary information from knowledge graphs to enhance recommendation performance. However, existing methods for knowledge enhanced recommendation often overlook the issues of the non ...
Shuai Chen, Zhoujun Li
doaj +1 more source
Software Development Practices in Global Software Work : Developing Quality Software
, 2005 This thesis is about software development practices, including the project management aspects, in the context of global software outsourcing. It was focused on the issues of achieving quality product namely here: software. It is built on the premise that the global context, in which the stakeholders are geographically separated by national boundaries ...
openaire +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Reconfigurability Function Deployment in Software Development [PDF]
In the forthcoming highly dynamic and complex business environment high-speed and cost-effective development of software applications for targeting a precise, unique and momentary set of requirements (no more-no less) associated to a customized business ...
Adrian CHIOREANU +4 more
core
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Monitoring software development through dynamic variables [PDF]
Research conducted by the Software Engineering Laboratory (SEL) on the use of dynamic variables as a tool to monitor software development is described.
Basili, Victor R., Doerflinger, Carl W.
core +1 more source